FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157776107> ?p ?o ?g. }

• W2157776107 endingPage "105" @default.
• W2157776107 startingPage "99" @default.
• W2157776107 abstract "Gliomas frequently display constitutive activation of the transcription factor STAT3, a protein that is known to be able to mediate neoplastic transformation. STAT3 regulates genes that play a central role in cellular survival, proliferation, self-renewal, and invasion, and a cohort of STAT3 target genes have been found that are commonly coexpressed in human cancers. Thus, these genes likely subserve the transforming ability of constitutively activated STAT3. To determine whether the coordinated expression of STAT3 target genes is present in a subset of human gliomas, and whether this changes the biology of these tumors in patients, gene expression analysis was performed in four distinct human glioma data sets for which patient survival information was available. Coordinate expression of STAT3 targets was significantly associated with poor patient outcome in each data set. Specifically, patients with tumors displaying high expression of STAT3 targets had a shorter median survival time compared to patients whose tumors had low expression of STAT3 targets. These data suggest that constitutively activated STAT3 in gliomas can alter the biology of these tumors, and that development of targeted STAT3 inhibitors would likely be of particular benefit in treatment of this disease." @default.
• W2157776107 created "2016-06-24" @default.
• W2157776107 creator A5001528733 @default.
• W2157776107 creator A5013779863 @default.
• W2157776107 creator A5018381770 @default.
• W2157776107 creator A5018678406 @default.
• W2157776107 creator A5042821901 @default.
• W2157776107 creator A5046590023 @default.
• W2157776107 creator A5047880272 @default.
• W2157776107 creator A5062469108 @default.
• W2157776107 creator A5077784095 @default.
• W2157776107 date "2007-01-01" @default.
• W2157776107 modified "2023-10-16" @default.
• W2157776107 title "A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis" @default.
• W2157776107 cites W1210551670 @default.
• W2157776107 cites W1480917519 @default.
• W2157776107 cites W148432327 @default.
• W2157776107 cites W1551136530 @default.
• W2157776107 cites W1942750313 @default.
• W2157776107 cites W1969512609 @default.
• W2157776107 cites W1973071934 @default.
• W2157776107 cites W1980480652 @default.
• W2157776107 cites W2011504208 @default.
• W2157776107 cites W2013420022 @default.
• W2157776107 cites W2027844138 @default.
• W2157776107 cites W2033480740 @default.
• W2157776107 cites W2034269086 @default.
• W2157776107 cites W2044268362 @default.
• W2157776107 cites W2052432571 @default.
• W2157776107 cites W2071771054 @default.
• W2157776107 cites W2074356752 @default.
• W2157776107 cites W2083802827 @default.
• W2157776107 cites W2086715846 @default.
• W2157776107 cites W2099708088 @default.
• W2157776107 cites W2108819945 @default.
• W2157776107 cites W2114098415 @default.
• W2157776107 cites W2114998237 @default.
• W2157776107 cites W2119005247 @default.
• W2157776107 cites W2126890008 @default.
• W2157776107 cites W2130410032 @default.
• W2157776107 cites W2131152510 @default.
• W2157776107 cites W2141016223 @default.
• W2157776107 doi "https://doi.org/10.4137/tog.s1903" @default.
• W2157776107 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3634710" @default.
• W2157776107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23641147" @default.
• W2157776107 hasPublicationYear "2007" @default.
• W2157776107 type Work @default.
• W2157776107 sameAs 2157776107 @default.
• W2157776107 citedByCount "22" @default.
• W2157776107 countsByYear W21577761072013 @default.
• W2157776107 countsByYear W21577761072014 @default.
• W2157776107 countsByYear W21577761072015 @default.
• W2157776107 countsByYear W21577761072016 @default.
• W2157776107 countsByYear W21577761072017 @default.
• W2157776107 countsByYear W21577761072019 @default.
• W2157776107 countsByYear W21577761072020 @default.
• W2157776107 countsByYear W21577761072021 @default.
• W2157776107 countsByYear W21577761072022 @default.
• W2157776107 crossrefType "journal-article" @default.
• W2157776107 hasAuthorship W2157776107A5001528733 @default.
• W2157776107 hasAuthorship W2157776107A5013779863 @default.
• W2157776107 hasAuthorship W2157776107A5018381770 @default.
• W2157776107 hasAuthorship W2157776107A5018678406 @default.
• W2157776107 hasAuthorship W2157776107A5042821901 @default.
• W2157776107 hasAuthorship W2157776107A5046590023 @default.
• W2157776107 hasAuthorship W2157776107A5047880272 @default.
• W2157776107 hasAuthorship W2157776107A5062469108 @default.
• W2157776107 hasAuthorship W2157776107A5077784095 @default.
• W2157776107 hasBestOaLocation W21577761072 @default.
• W2157776107 hasConcept C104317684 @default.
• W2157776107 hasConcept C150194340 @default.
• W2157776107 hasConcept C2778227246 @default.
• W2157776107 hasConcept C2778923194 @default.
• W2157776107 hasConcept C2779733811 @default.
• W2157776107 hasConcept C502942594 @default.
• W2157776107 hasConcept C54355233 @default.
• W2157776107 hasConcept C86339819 @default.
• W2157776107 hasConcept C86803240 @default.
• W2157776107 hasConceptScore W2157776107C104317684 @default.
• W2157776107 hasConceptScore W2157776107C150194340 @default.
• W2157776107 hasConceptScore W2157776107C2778227246 @default.
• W2157776107 hasConceptScore W2157776107C2778923194 @default.
• W2157776107 hasConceptScore W2157776107C2779733811 @default.
• W2157776107 hasConceptScore W2157776107C502942594 @default.
• W2157776107 hasConceptScore W2157776107C54355233 @default.
• W2157776107 hasConceptScore W2157776107C86339819 @default.
• W2157776107 hasConceptScore W2157776107C86803240 @default.
• W2157776107 hasLocation W21577761071 @default.
• W2157776107 hasLocation W21577761072 @default.
• W2157776107 hasLocation W21577761073 @default.
• W2157776107 hasLocation W21577761074 @default.
• W2157776107 hasLocation W21577761075 @default.
• W2157776107 hasLocation W21577761076 @default.
• W2157776107 hasOpenAccess W2157776107 @default.
• W2157776107 hasPrimaryLocation W21577761071 @default.
• W2157776107 hasRelatedWork W2009966535 @default.
• W2157776107 hasRelatedWork W2353932375 @default.
• W2157776107 hasRelatedWork W2388601503 @default.

• next