FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157791454> ?p ?o ?g. }

• W2157791454 endingPage "no" @default.
• W2157791454 startingPage "no" @default.
• W2157791454 abstract "Background: Preclinical studies have implicated GABAergic neurosteroids in behavioral responses to alcohol. Naltrexone is thought to blunt the reinforcing effects of alcohol, and a few studies have found that the effects of naltrexone are moderated by the Asn40Asp polymorphisms of the OPRM1 gene. The present study seeks to integrate these lines of research by testing (i) the moderating role of the functional Asn40Asp polymorphism of the OPRM1 gene on naltrexone-induced alternations in GABAergic neurosteroid levels, namely (3α,5α)-3-hydroxypregnan-20-one (allopregnanolone, ALLO); and (ii) the combined effects of naltrexone or genotype with alcohol administration on neurosteroid levels in a sample of at-risk drinkers. Methods: Participants were 32 (9 females) nontreatment-seeking heavy drinkers who completed a placebo-controlled laboratory study of naltrexone (50 mg/d for 3 days) and provided complete sets of serum samples for ALLO assays before and after alcohol administration under both naltrexone and placebo conditions. Results: Naltrexone treatment raised ALLO levels among carriers of the Asp40 allele, but not homozygotes for the Asn40 allele. The Asn40Asp polymorphism did not moderate effects of naltrexone on cortisol levels. Ethanol infusion modestly reduced ALLO levels in all subjects, independent of genotype or naltrexone exposure. Conclusions: Naltrexone increased ALLO levels among individuals with the Asn40Asp allele suggesting a potential neurosteroid contribution to the neuropharmacological effects of naltrexone among Asp40 carriers." @default.
• W2157791454 created "2016-06-24" @default.
• W2157791454 creator A5007663400 @default.
• W2157791454 creator A5024081434 @default.
• W2157791454 creator A5039382744 @default.
• W2157791454 creator A5078922068 @default.
• W2157791454 date "2010-06-07" @default.
• W2157791454 modified "2023-10-17" @default.
• W2157791454 title "Naltrexone Selectively Elevates GABAergic Neuroactive Steroid Levels in Heavy Drinkers With the ASP40 Allele of the OPRM1 Gene: A Pilot Investigation" @default.
• W2157791454 cites W1480443500 @default.
• W2157791454 cites W1555167676 @default.
• W2157791454 cites W1626578772 @default.
• W2157791454 cites W1922154348 @default.
• W2157791454 cites W1972408435 @default.
• W2157791454 cites W1976334278 @default.
• W2157791454 cites W1980637329 @default.
• W2157791454 cites W1991038498 @default.
• W2157791454 cites W1991155846 @default.
• W2157791454 cites W1993187344 @default.
• W2157791454 cites W2000712333 @default.
• W2157791454 cites W2006594166 @default.
• W2157791454 cites W2020045114 @default.
• W2157791454 cites W2024344189 @default.
• W2157791454 cites W2024350454 @default.
• W2157791454 cites W2024605730 @default.
• W2157791454 cites W2024776736 @default.
• W2157791454 cites W2026927992 @default.
• W2157791454 cites W2031351244 @default.
• W2157791454 cites W2031458111 @default.
• W2157791454 cites W2032321294 @default.
• W2157791454 cites W2033102020 @default.
• W2157791454 cites W2039686797 @default.
• W2157791454 cites W2040309911 @default.
• W2157791454 cites W2044560641 @default.
• W2157791454 cites W2050844190 @default.
• W2157791454 cites W2052511485 @default.
• W2157791454 cites W2055080711 @default.
• W2157791454 cites W2071961991 @default.
• W2157791454 cites W2072990514 @default.
• W2157791454 cites W2074406420 @default.
• W2157791454 cites W2076355273 @default.
• W2157791454 cites W2078568826 @default.
• W2157791454 cites W2078870362 @default.
• W2157791454 cites W2079726518 @default.
• W2157791454 cites W2083257590 @default.
• W2157791454 cites W2083552615 @default.
• W2157791454 cites W2084664557 @default.
• W2157791454 cites W2084775431 @default.
• W2157791454 cites W2092120977 @default.
• W2157791454 cites W2093559862 @default.
• W2157791454 cites W2101372918 @default.
• W2157791454 cites W2104372273 @default.
• W2157791454 cites W2104538950 @default.
• W2157791454 cites W2108651428 @default.
• W2157791454 cites W2111101816 @default.
• W2157791454 cites W2117619438 @default.
• W2157791454 cites W2118773914 @default.
• W2157791454 cites W2127564371 @default.
• W2157791454 cites W2130762071 @default.
• W2157791454 cites W2131350997 @default.
• W2157791454 cites W2142494970 @default.
• W2157791454 cites W2150715760 @default.
• W2157791454 cites W2150857791 @default.
• W2157791454 cites W2155026843 @default.
• W2157791454 cites W2159407436 @default.
• W2157791454 cites W2160916899 @default.
• W2157791454 cites W2162530578 @default.
• W2157791454 cites W2169863475 @default.
• W2157791454 cites W2171013703 @default.
• W2157791454 cites W2171196764 @default.
• W2157791454 cites W2338719804 @default.
• W2157791454 cites W27026517 @default.
• W2157791454 cites W4322697749 @default.
• W2157791454 cites W51532465 @default.
• W2157791454 doi "https://doi.org/10.1111/j.1530-0277.2010.01233.x" @default.
• W2157791454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20528823" @default.
• W2157791454 hasPublicationYear "2010" @default.
• W2157791454 type Work @default.
• W2157791454 sameAs 2157791454 @default.
• W2157791454 citedByCount "5" @default.
• W2157791454 countsByYear W21577914542013 @default.
• W2157791454 countsByYear W21577914542014 @default.
• W2157791454 countsByYear W21577914542020 @default.
• W2157791454 countsByYear W21577914542021 @default.
• W2157791454 crossrefType "journal-article" @default.
• W2157791454 hasAuthorship W2157791454A5007663400 @default.
• W2157791454 hasAuthorship W2157791454A5024081434 @default.
• W2157791454 hasAuthorship W2157791454A5039382744 @default.
• W2157791454 hasAuthorship W2157791454A5078922068 @default.
• W2157791454 hasConcept C126322002 @default.
• W2157791454 hasConcept C134018914 @default.
• W2157791454 hasConcept C142724271 @default.
• W2157791454 hasConcept C15744967 @default.
• W2157791454 hasConcept C168258287 @default.
• W2157791454 hasConcept C170493617 @default.
• W2157791454 hasConcept C204787440 @default.
• W2157791454 hasConcept C27081682 @default.
• W2157791454 hasConcept C2776885963 @default.

• next