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- W2157796632 abstract "The generation of the mammalian heartbeat is a complex and vital function requiring multiple and coordinated ionic channel activities. The functional role of low-voltage activated (LVA) T-type calcium channels in the pacemaker activity of the sinoatrial node (SAN) is, to date, unresolved. Here we show that disruption of the gene coding for CaV3.1/alpha1G T-type calcium channels (cacna1g) abolishes T-type calcium current (I(Ca,T)) in isolated cells from the SAN and the atrioventricular node without affecting the L-type Ca2+ current (I(Ca,L)). By using telemetric electrocardiograms on unrestrained mice and intracardiac recordings, we find that cacna1g inactivation causes bradycardia and delays atrioventricular conduction without affecting the excitability of the right atrium. Consistently, no I(Ca,T) was detected in right atrium myocytes in both wild-type and CaV3.1(-/-) mice. Furthermore, inactivation of cacna1g significantly slowed the intrinsic in vivo heart rate, prolonged the SAN recovery time, and slowed pacemaker activity of individual SAN cells through a reduction of the slope of the diastolic depolarization. Our results demonstrate that CaV3.1/T-type Ca2+ channels contribute to SAN pacemaker activity and atrioventricular conduction." @default.
- W2157796632 created "2016-06-24" @default.
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- W2157796632 date "2006-06-09" @default.
- W2157796632 modified "2023-10-14" @default.
- W2157796632 title "Bradycardia and Slowing of the Atrioventricular Conduction in Mice Lacking Ca <sub>V</sub> 3.1/α <sub>1G</sub> T-Type Calcium Channels" @default.
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- W2157796632 doi "https://doi.org/10.1161/01.res.0000225862.14314.49" @default.
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