FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157796703> ?p ?o ?g. }

• W2157796703 endingPage "572" @default.
• W2157796703 startingPage "557" @default.
• W2157796703 abstract "Creatine kinase catalyzes the reversible transfer of the gamma phosphate from ATP to creatine forming the high energy compound creatine phosphate. Muscle creatine kinase (CKm) activity maintains energetic homeostasis as variations in energy requirements dictate that ATP be readily available. Recent studies suggest that CKm activity is altered during aging. Proteomic analyses have shown that CKm is 3-nitrotyrosine (3-NT) modified and carbonylated in aged rodent skeletal muscle. However, it remains unknown if these modifications affect its structure and activity. To address this we characterized oxidatively modified CKm from the quadriceps of young, middle-aged, and aged mice. Our data indicate that 3-NT modified and carbonylated CKm are found predominantly in aged muscle and that it exists in high molecular weight oligomers and insoluble protein aggregates. CKm from middle-aged and aged mouse quadriceps also exhibits structural instability that may account for its reduction in function. These structural and functional changes correlate with the differential protein modifications. Interestingly, the majority of the age-related changes in enzyme activity and protein stability occurred by middle age. Our studies indicate that the age-associated oxidative and nitrative modification of CKm results in a decrease in its activity and may cause structural changes that promote oligomerization and aggregation." @default.
• W2157796703 created "2016-06-24" @default.
• W2157796703 creator A5010249172 @default.
• W2157796703 creator A5013372896 @default.
• W2157796703 creator A5031759633 @default.
• W2157796703 creator A5038282016 @default.
• W2157796703 creator A5069776052 @default.
• W2157796703 creator A5082440020 @default.
• W2157796703 creator A5089081225 @default.
• W2157796703 date "2009-05-22" @default.
• W2157796703 modified "2023-09-23" @default.
• W2157796703 title "Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle" @default.
• W2157796703 cites W1274506549 @default.
• W2157796703 cites W145825086 @default.
• W2157796703 cites W1479846693 @default.
• W2157796703 cites W1483267297 @default.
• W2157796703 cites W1486968954 @default.
• W2157796703 cites W1506520614 @default.
• W2157796703 cites W1509382673 @default.
• W2157796703 cites W1577450737 @default.
• W2157796703 cites W1581858536 @default.
• W2157796703 cites W1595778460 @default.
• W2157796703 cites W1606532905 @default.
• W2157796703 cites W1860090481 @default.
• W2157796703 cites W1963806357 @default.
• W2157796703 cites W1969083592 @default.
• W2157796703 cites W1972646050 @default.
• W2157796703 cites W1977824466 @default.
• W2157796703 cites W1979529612 @default.
• W2157796703 cites W1985431868 @default.
• W2157796703 cites W1986005076 @default.
• W2157796703 cites W1988347671 @default.
• W2157796703 cites W1996186591 @default.
• W2157796703 cites W1999736053 @default.
• W2157796703 cites W2001137627 @default.
• W2157796703 cites W2010366556 @default.
• W2157796703 cites W2022812113 @default.
• W2157796703 cites W2025464379 @default.
• W2157796703 cites W2025887081 @default.
• W2157796703 cites W2026610762 @default.
• W2157796703 cites W2033893556 @default.
• W2157796703 cites W2037825839 @default.
• W2157796703 cites W2052618578 @default.
• W2157796703 cites W2055512409 @default.
• W2157796703 cites W2068301733 @default.
• W2157796703 cites W2076975501 @default.
• W2157796703 cites W2082441148 @default.
• W2157796703 cites W2086661624 @default.
• W2157796703 cites W2087292928 @default.
• W2157796703 cites W2087602854 @default.
• W2157796703 cites W2088849049 @default.
• W2157796703 cites W2090563896 @default.
• W2157796703 cites W2093375290 @default.
• W2157796703 cites W2107677733 @default.
• W2157796703 cites W2117327744 @default.
• W2157796703 cites W2119283806 @default.
• W2157796703 cites W2134057677 @default.
• W2157796703 cites W2140260269 @default.
• W2157796703 cites W2170295209 @default.
• W2157796703 cites W2333724197 @default.
• W2157796703 cites W4211019851 @default.
• W2157796703 doi "https://doi.org/10.18632/aging.100055" @default.
• W2157796703 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2830079" @default.
• W2157796703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20195383" @default.
• W2157796703 hasPublicationYear "2009" @default.
• W2157796703 type Work @default.
• W2157796703 sameAs 2157796703 @default.
• W2157796703 citedByCount "44" @default.
• W2157796703 countsByYear W21577967032012 @default.
• W2157796703 countsByYear W21577967032013 @default.
• W2157796703 countsByYear W21577967032014 @default.
• W2157796703 countsByYear W21577967032015 @default.
• W2157796703 countsByYear W21577967032016 @default.
• W2157796703 countsByYear W21577967032017 @default.
• W2157796703 countsByYear W21577967032018 @default.
• W2157796703 countsByYear W21577967032019 @default.
• W2157796703 countsByYear W21577967032020 @default.
• W2157796703 countsByYear W21577967032021 @default.
• W2157796703 countsByYear W21577967032022 @default.
• W2157796703 countsByYear W21577967032023 @default.
• W2157796703 crossrefType "journal-article" @default.
• W2157796703 hasAuthorship W2157796703A5010249172 @default.
• W2157796703 hasAuthorship W2157796703A5013372896 @default.
• W2157796703 hasAuthorship W2157796703A5031759633 @default.
• W2157796703 hasAuthorship W2157796703A5038282016 @default.
• W2157796703 hasAuthorship W2157796703A5069776052 @default.
• W2157796703 hasAuthorship W2157796703A5082440020 @default.
• W2157796703 hasAuthorship W2157796703A5089081225 @default.
• W2157796703 hasBestOaLocation W21577967031 @default.
• W2157796703 hasConcept C12554922 @default.
• W2157796703 hasConcept C126322002 @default.
• W2157796703 hasConcept C134018914 @default.
• W2157796703 hasConcept C181199279 @default.
• W2157796703 hasConcept C185592680 @default.
• W2157796703 hasConcept C2779896295 @default.
• W2157796703 hasConcept C2779959927 @default.
• W2157796703 hasConcept C36880943 @default.
• W2157796703 hasConcept C55493867 @default.

• next