Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157796706> ?p ?o ?g. }
- W2157796706 endingPage "7196" @default.
- W2157796706 startingPage "7188" @default.
- W2157796706 abstract "Rapsyn is a synapse-specific protein that is required for clustering acetylcholine receptors at the neuromuscular junction. Analysis of the rapsyn promoter revealed a consensus site for the transcription factor Kaiso within a region that is mutated in a subset of patients with congenital myasthenic syndrome. Kaiso is a POZ-zinc finger family transcription factor which recognizes the specific core consensus sequence CTGCNA (where N is any nucleotide). Previously, the only known binding partner for Kaiso was the cell adhesion cofactor, p120 catenin. Here we show that δ-catenin, a brain-specific member of the p120 catenin subfamily, forms a complex with Kaiso. Antibodies against Kaiso and δ-catenin recognize proteins in the nuclei of C2C12 myocytes and at the postsynaptic domain of the mouse neuromuscular junction. Endogenous Kaiso in C2C12 cells coprecipitates with the rapsyn promoter in vivo as shown by chromatin immunoprecipitation assay. Minimal promoter assays demonstrated that the rapsyn promoter can be activated by Kaiso and δ-catenin; this activation is apparently muscle specific. These results provide the first experimental evidence that rapsyn is a direct sequence-specific target of Kaiso and δ-catenin. We propose a new model of synapse-specific transcription that involves the interaction of Kaiso, δ-catenin, and myogenic transcription factors at the neuromuscular junction." @default.
- W2157796706 created "2016-06-24" @default.
- W2157796706 creator A5023973125 @default.
- W2157796706 creator A5030612899 @default.
- W2157796706 creator A5036458814 @default.
- W2157796706 creator A5039822490 @default.
- W2157796706 creator A5061000332 @default.
- W2157796706 date "2004-08-01" @default.
- W2157796706 modified "2023-10-16" @default.
- W2157796706 title "Regulation of the Rapsyn Promoter by Kaiso and δ-Catenin" @default.
- W2157796706 cites W1859151740 @default.
- W2157796706 cites W1951809136 @default.
- W2157796706 cites W1970681929 @default.
- W2157796706 cites W1974018051 @default.
- W2157796706 cites W1978735852 @default.
- W2157796706 cites W1980061153 @default.
- W2157796706 cites W1981644750 @default.
- W2157796706 cites W1983841377 @default.
- W2157796706 cites W1988435915 @default.
- W2157796706 cites W1994510778 @default.
- W2157796706 cites W1998849358 @default.
- W2157796706 cites W2006340329 @default.
- W2157796706 cites W2016056829 @default.
- W2157796706 cites W2017340736 @default.
- W2157796706 cites W2040092085 @default.
- W2157796706 cites W2047219476 @default.
- W2157796706 cites W2051270549 @default.
- W2157796706 cites W2053723917 @default.
- W2157796706 cites W2056920813 @default.
- W2157796706 cites W2077078276 @default.
- W2157796706 cites W2083486038 @default.
- W2157796706 cites W2084432143 @default.
- W2157796706 cites W2085995080 @default.
- W2157796706 cites W2089288166 @default.
- W2157796706 cites W2089397118 @default.
- W2157796706 cites W2090839493 @default.
- W2157796706 cites W2093992216 @default.
- W2157796706 cites W2098323244 @default.
- W2157796706 cites W2101143531 @default.
- W2157796706 cites W2112937983 @default.
- W2157796706 cites W2115324794 @default.
- W2157796706 cites W2120492811 @default.
- W2157796706 cites W2121893023 @default.
- W2157796706 cites W2123812291 @default.
- W2157796706 cites W2131860370 @default.
- W2157796706 cites W2134505400 @default.
- W2157796706 cites W2139650552 @default.
- W2157796706 cites W2143528416 @default.
- W2157796706 cites W2148760132 @default.
- W2157796706 cites W2150876347 @default.
- W2157796706 cites W2152025793 @default.
- W2157796706 cites W2163311832 @default.
- W2157796706 cites W2164592902 @default.
- W2157796706 cites W2167594266 @default.
- W2157796706 cites W4322699968 @default.
- W2157796706 doi "https://doi.org/10.1128/mcb.24.16.7188-7196.2004" @default.
- W2157796706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/479716" @default.
- W2157796706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15282317" @default.
- W2157796706 hasPublicationYear "2004" @default.
- W2157796706 type Work @default.
- W2157796706 sameAs 2157796706 @default.
- W2157796706 citedByCount "105" @default.
- W2157796706 countsByYear W21577967062012 @default.
- W2157796706 countsByYear W21577967062013 @default.
- W2157796706 countsByYear W21577967062014 @default.
- W2157796706 countsByYear W21577967062015 @default.
- W2157796706 countsByYear W21577967062016 @default.
- W2157796706 countsByYear W21577967062017 @default.
- W2157796706 countsByYear W21577967062018 @default.
- W2157796706 countsByYear W21577967062019 @default.
- W2157796706 countsByYear W21577967062020 @default.
- W2157796706 countsByYear W21577967062021 @default.
- W2157796706 countsByYear W21577967062022 @default.
- W2157796706 countsByYear W21577967062023 @default.
- W2157796706 crossrefType "journal-article" @default.
- W2157796706 hasAuthorship W2157796706A5023973125 @default.
- W2157796706 hasAuthorship W2157796706A5030612899 @default.
- W2157796706 hasAuthorship W2157796706A5036458814 @default.
- W2157796706 hasAuthorship W2157796706A5039822490 @default.
- W2157796706 hasAuthorship W2157796706A5061000332 @default.
- W2157796706 hasBestOaLocation W21577967062 @default.
- W2157796706 hasConcept C101762097 @default.
- W2157796706 hasConcept C104317684 @default.
- W2157796706 hasConcept C134320426 @default.
- W2157796706 hasConcept C150194340 @default.
- W2157796706 hasConcept C169760540 @default.
- W2157796706 hasConcept C207200792 @default.
- W2157796706 hasConcept C25602115 @default.
- W2157796706 hasConcept C2777240379 @default.
- W2157796706 hasConcept C2778106681 @default.
- W2157796706 hasConcept C3763915 @default.
- W2157796706 hasConcept C54355233 @default.
- W2157796706 hasConcept C60278653 @default.
- W2157796706 hasConcept C86339819 @default.
- W2157796706 hasConcept C86803240 @default.
- W2157796706 hasConcept C95444343 @default.
- W2157796706 hasConceptScore W2157796706C101762097 @default.
- W2157796706 hasConceptScore W2157796706C104317684 @default.