FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157804532> ?p ?o ?g. }

• W2157804532 endingPage "780" @default.
• W2157804532 startingPage "771" @default.
• W2157804532 abstract "Abstract The Slx5–Slx8 complex is a ubiquitin ligase that preferentially ubiquitylates SUMOylated substrates, targeting them for proteolysis. Mutations in SLX5, SLX8, and other SUMO pathway genes were previously identified in our laboratory as genomic suppressors of a point mutation (mot1-301) in the transcriptional regulator MOT1. To further understand the links between the SUMO and ubiquitin pathways, a screen was performed for high-copy suppressors of mot1-301, yielding three genes (MOT3, MIT1, and ULS1). MOT3 and MIT1 have characteristics of prions, and ULS1 is believed to encode another SUMO-targeted ubiquitin ligase (STUbL) that functionally overlaps with Slx5-Slx8. Here we focus on ULS1, obtaining results suggesting that the relationship between ULS1 and SLX5 is more complex than expected. Uls1 interacted with Slx5 physically in to yeast two-hybrid and co-immunoprecipitation assays, a uls1 mutation that blocked the interaction between Uls1 and Slx5 interfered with ULS1 function, and genetic analyses indicated an antagonistic relationship between ULS1 and SLX5. Combined, our results challenge the assumption that Uls1 and Slx5 are simply partially overlapping STUbLs and begin to illuminate a regulatory relationship between these two proteins." @default.
• W2157804532 created "2016-06-24" @default.
• W2157804532 creator A5047142471 @default.
• W2157804532 creator A5052267876 @default.
• W2157804532 creator A5075486570 @default.
• W2157804532 date "2013-04-01" @default.
• W2157804532 modified "2023-09-26" @default.
• W2157804532 title "Physical and Genetic Interactions Between Uls1 and the Slx5–Slx8 SUMO-Targeted Ubiquitin Ligase" @default.
• W2157804532 cites W1490806999 @default.
• W2157804532 cites W1810529501 @default.
• W2157804532 cites W1903792504 @default.
• W2157804532 cites W1970061483 @default.
• W2157804532 cites W1978078396 @default.
• W2157804532 cites W1978783141 @default.
• W2157804532 cites W1981700185 @default.
• W2157804532 cites W1985442694 @default.
• W2157804532 cites W1985705452 @default.
• W2157804532 cites W1987129537 @default.
• W2157804532 cites W1997369314 @default.
• W2157804532 cites W2000204824 @default.
• W2157804532 cites W2002879843 @default.
• W2157804532 cites W2004737134 @default.
• W2157804532 cites W2005702576 @default.
• W2157804532 cites W2012618272 @default.
• W2157804532 cites W2013108773 @default.
• W2157804532 cites W2013970469 @default.
• W2157804532 cites W2021618108 @default.
• W2157804532 cites W2023611162 @default.
• W2157804532 cites W2039741753 @default.
• W2157804532 cites W2044229112 @default.
• W2157804532 cites W2044287615 @default.
• W2157804532 cites W2046037983 @default.
• W2157804532 cites W2047166991 @default.
• W2157804532 cites W2048371609 @default.
• W2157804532 cites W2053060343 @default.
• W2157804532 cites W2055144036 @default.
• W2157804532 cites W2058289056 @default.
• W2157804532 cites W2064127615 @default.
• W2157804532 cites W2066889359 @default.
• W2157804532 cites W2071475568 @default.
• W2157804532 cites W2073148985 @default.
• W2157804532 cites W2074177924 @default.
• W2157804532 cites W2094209629 @default.
• W2157804532 cites W2095617518 @default.
• W2157804532 cites W2100200896 @default.
• W2157804532 cites W2104485246 @default.
• W2157804532 cites W2104746448 @default.
• W2157804532 cites W2105831706 @default.
• W2157804532 cites W2108228282 @default.
• W2157804532 cites W2111426001 @default.
• W2157804532 cites W2114405956 @default.
• W2157804532 cites W2119651404 @default.
• W2157804532 cites W2123256728 @default.
• W2157804532 cites W2124501260 @default.
• W2157804532 cites W2134962337 @default.
• W2157804532 cites W2136128861 @default.
• W2157804532 cites W2137158072 @default.
• W2157804532 cites W2144114582 @default.
• W2157804532 cites W2149867107 @default.
• W2157804532 cites W2170014373 @default.
• W2157804532 cites W2183630872 @default.
• W2157804532 cites W2436036140 @default.
• W2157804532 doi "https://doi.org/10.1534/g3.113.005827" @default.
• W2157804532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3618364" @default.
• W2157804532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23550137" @default.
• W2157804532 hasPublicationYear "2013" @default.
• W2157804532 type Work @default.
• W2157804532 sameAs 2157804532 @default.
• W2157804532 citedByCount "12" @default.
• W2157804532 countsByYear W21578045322014 @default.
• W2157804532 countsByYear W21578045322016 @default.
• W2157804532 countsByYear W21578045322017 @default.
• W2157804532 countsByYear W21578045322019 @default.
• W2157804532 countsByYear W21578045322021 @default.
• W2157804532 countsByYear W21578045322022 @default.
• W2157804532 crossrefType "journal-article" @default.
• W2157804532 hasAuthorship W2157804532A5047142471 @default.
• W2157804532 hasAuthorship W2157804532A5052267876 @default.
• W2157804532 hasAuthorship W2157804532A5075486570 @default.
• W2157804532 hasBestOaLocation W21578045322 @default.
• W2157804532 hasConcept C104317684 @default.
• W2157804532 hasConcept C134459356 @default.
• W2157804532 hasConcept C14036430 @default.
• W2157804532 hasConcept C171350616 @default.
• W2157804532 hasConcept C175114707 @default.
• W2157804532 hasConcept C176944494 @default.
• W2157804532 hasConcept C179185449 @default.
• W2157804532 hasConcept C25602115 @default.
• W2157804532 hasConcept C2908868211 @default.
• W2157804532 hasConcept C501734568 @default.
• W2157804532 hasConcept C54355233 @default.
• W2157804532 hasConcept C6929976 @default.
• W2157804532 hasConcept C71829478 @default.
• W2157804532 hasConcept C86803240 @default.
• W2157804532 hasConcept C95444343 @default.
• W2157804532 hasConceptScore W2157804532C104317684 @default.
• W2157804532 hasConceptScore W2157804532C134459356 @default.
• W2157804532 hasConceptScore W2157804532C14036430 @default.

• next