FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157836985> ?p ?o ?g. }

• W2157836985 endingPage "4753" @default.
• W2157836985 startingPage "4746" @default.
• W2157836985 abstract "To date, no data are available on the relationship between 1p/19q deletions and the response to temozolomide (TMZ) in primary anaplastic oligodendroglioma (AO) and anaplastic oligoastrocytoma (AOA) recurrent after surgery and standard radiotherapy. The aim of this study was to evaluate correlations between 1p/19q deletions, O6-methylguanine DNA methyltransferase (MGMT) promoter methylation, and response rate to TMZ in this setting.From June 2000 to February 2005, 67 patients were enrolled; 39 patients (58%) had AO and 28 patients (42%) had AOA. All patients received 150 to 200 mg/m2 of TMZ every 28 days. Chromosome 1p and 19q deletions were detected by fluorescence in situ hybridization and MGMT promoter methylation was analyzed using methylation specific polymerase chain reaction.The overall response rate was 46.3% (17 complete responses and 14 partial responses). The response rate was higher in patients with AO than in those with AOA (61.5% v 25%, P = .003). Combined 1p/19q allelic loss was found in 32 patients (47.8%), while MGMT methylation occurred in 37 (68.5%) of 54 assessable patients. 1p/19q loss was significantly correlated with response rate (P = .04), time-to-progression (P = .003), and overall survival (P = .0001). Despite the significant concordance found between MGMT promoter methylation and 1p/19q deletions (P = .02), MGMT promoter methylation showed only a borderline correlation with overall survival (P = .09).TMZ is active in anaplastic oligodendroglial tumors treated at first recurrence. In this setting, 1p/19q allelic loss is an important predictive and prognostic factor. Further studies on MGMT promoter methylation should be performed in randomized trials to test its correlation with survival." @default.
• W2157836985 created "2016-06-24" @default.
• W2157836985 creator A5015384601 @default.
• W2157836985 creator A5019091770 @default.
• W2157836985 creator A5021321101 @default.
• W2157836985 creator A5029155675 @default.
• W2157836985 creator A5033909956 @default.
• W2157836985 creator A5038760660 @default.
• W2157836985 creator A5040390892 @default.
• W2157836985 creator A5042005891 @default.
• W2157836985 creator A5042347653 @default.
• W2157836985 creator A5047678826 @default.
• W2157836985 creator A5049960947 @default.
• W2157836985 creator A5063327760 @default.
• W2157836985 creator A5063984232 @default.
• W2157836985 date "2006-10-10" @default.
• W2157836985 modified "2023-10-16" @default.
• W2157836985 title "Correlations Between O6-Methylguanine DNA Methyltransferase Promoter Methylation Status, 1p and 19q Deletions, and Response to Temozolomide in Anaplastic and Recurrent Oligodendroglioma: A Prospective GICNO Study" @default.
• W2157836985 cites W1536266814 @default.
• W2157836985 cites W1751296883 @default.
• W2157836985 cites W1959628099 @default.
• W2157836985 cites W1994465394 @default.
• W2157836985 cites W2001493754 @default.
• W2157836985 cites W2046289133 @default.
• W2157836985 cites W2056529936 @default.
• W2157836985 cites W2068795211 @default.
• W2157836985 cites W2074242592 @default.
• W2157836985 cites W2089857550 @default.
• W2157836985 cites W2095175330 @default.
• W2157836985 cites W2098548617 @default.
• W2157836985 cites W2098785952 @default.
• W2157836985 cites W2105100844 @default.
• W2157836985 cites W2114753552 @default.
• W2157836985 cites W2131518655 @default.
• W2157836985 cites W2141431050 @default.
• W2157836985 cites W2263732046 @default.
• W2157836985 cites W2328946792 @default.
• W2157836985 cites W2413323251 @default.
• W2157836985 cites W4251413814 @default.
• W2157836985 doi "https://doi.org/10.1200/jco.2006.06.3891" @default.
• W2157836985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16954518" @default.
• W2157836985 hasPublicationYear "2006" @default.
• W2157836985 type Work @default.
• W2157836985 sameAs 2157836985 @default.
• W2157836985 citedByCount "176" @default.
• W2157836985 countsByYear W21578369852012 @default.
• W2157836985 countsByYear W21578369852013 @default.
• W2157836985 countsByYear W21578369852014 @default.
• W2157836985 countsByYear W21578369852015 @default.
• W2157836985 countsByYear W21578369852016 @default.
• W2157836985 countsByYear W21578369852017 @default.
• W2157836985 countsByYear W21578369852018 @default.
• W2157836985 countsByYear W21578369852019 @default.
• W2157836985 countsByYear W21578369852020 @default.
• W2157836985 countsByYear W21578369852021 @default.
• W2157836985 countsByYear W21578369852022 @default.
• W2157836985 countsByYear W21578369852023 @default.
• W2157836985 crossrefType "journal-article" @default.
• W2157836985 hasAuthorship W2157836985A5015384601 @default.
• W2157836985 hasAuthorship W2157836985A5019091770 @default.
• W2157836985 hasAuthorship W2157836985A5021321101 @default.
• W2157836985 hasAuthorship W2157836985A5029155675 @default.
• W2157836985 hasAuthorship W2157836985A5033909956 @default.
• W2157836985 hasAuthorship W2157836985A5038760660 @default.
• W2157836985 hasAuthorship W2157836985A5040390892 @default.
• W2157836985 hasAuthorship W2157836985A5042005891 @default.
• W2157836985 hasAuthorship W2157836985A5042347653 @default.
• W2157836985 hasAuthorship W2157836985A5047678826 @default.
• W2157836985 hasAuthorship W2157836985A5049960947 @default.
• W2157836985 hasAuthorship W2157836985A5063327760 @default.
• W2157836985 hasAuthorship W2157836985A5063984232 @default.
• W2157836985 hasConcept C104317684 @default.
• W2157836985 hasConcept C126322002 @default.
• W2157836985 hasConcept C143998085 @default.
• W2157836985 hasConcept C150194340 @default.
• W2157836985 hasConcept C190727270 @default.
• W2157836985 hasConcept C2777389519 @default.
• W2157836985 hasConcept C2777931997 @default.
• W2157836985 hasConcept C2778227246 @default.
• W2157836985 hasConcept C2778880634 @default.
• W2157836985 hasConcept C2779527866 @default.
• W2157836985 hasConcept C33288867 @default.
• W2157836985 hasConcept C502942594 @default.
• W2157836985 hasConcept C54355233 @default.
• W2157836985 hasConcept C71924100 @default.
• W2157836985 hasConcept C86803240 @default.
• W2157836985 hasConcept C91965660 @default.
• W2157836985 hasConceptScore W2157836985C104317684 @default.
• W2157836985 hasConceptScore W2157836985C126322002 @default.
• W2157836985 hasConceptScore W2157836985C143998085 @default.
• W2157836985 hasConceptScore W2157836985C150194340 @default.
• W2157836985 hasConceptScore W2157836985C190727270 @default.
• W2157836985 hasConceptScore W2157836985C2777389519 @default.
• W2157836985 hasConceptScore W2157836985C2777931997 @default.
• W2157836985 hasConceptScore W2157836985C2778227246 @default.
• W2157836985 hasConceptScore W2157836985C2778880634 @default.
• W2157836985 hasConceptScore W2157836985C2779527866 @default.
• W2157836985 hasConceptScore W2157836985C33288867 @default.

• next