Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157844270> ?p ?o ?g. }
- W2157844270 endingPage "5024" @default.
- W2157844270 startingPage "5014" @default.
- W2157844270 abstract "Zebrafish lost anterior teeth during evolution but retain a posterior pharyngeal dentition that requires retinoic acid (RA) cell-cell signaling for its development. The purposes of this study were to test the sufficiency of RA to induce tooth development and to assess its role in evolution. We found that exposure of embryos to exogenous RA induces a dramatic anterior expansion of the number of pharyngeal teeth that later form and shifts anteriorly the expression patterns of genes normally expressed in the posterior tooth-forming region, such as pitx2 and dlx2b. After RA exposure, we also observed a correlation between cartilage malformations and ectopic tooth induction, as well as abnormal cranial neural crest marker gene expression. Additionally, we observed that the RA-induced zebrafish anterior teeth resemble in pattern and number the dentition of fish species that retain anterior pharyngeal teeth such as medaka but that medaka do not express the aldh1a2 RA-synthesizing enzyme in tooth-forming regions. We conclude that RA is sufficient to induce anterior ectopic tooth development in zebrafish where teeth were lost in evolution, potentially by altering neural crest cell development, and that changes in the location of RA synthesis correlate with evolutionary changes in vertebrate dentitions.—Seritrakul, P., Samarut, E., Lama, T. T. S., Gibert, Y., Laudet, V., Jackman, W. R. Retinoic acid expands the evolutionarily reduced dentition of zebrafish. FASEB J. 26, 5014–5024 (2012). www.fasebj.org" @default.
- W2157844270 created "2016-06-24" @default.
- W2157844270 creator A5009735966 @default.
- W2157844270 creator A5013249789 @default.
- W2157844270 creator A5026882399 @default.
- W2157844270 creator A5045029936 @default.
- W2157844270 creator A5073410181 @default.
- W2157844270 creator A5089653205 @default.
- W2157844270 date "2012-08-31" @default.
- W2157844270 modified "2023-10-14" @default.
- W2157844270 title "Retinoic acid expands the evolutionarily reduced dentition of zebrafish" @default.
- W2157844270 cites W1547869018 @default.
- W2157844270 cites W1634383009 @default.
- W2157844270 cites W1834486239 @default.
- W2157844270 cites W1900387077 @default.
- W2157844270 cites W1963330390 @default.
- W2157844270 cites W1968916721 @default.
- W2157844270 cites W1973726394 @default.
- W2157844270 cites W1974723367 @default.
- W2157844270 cites W1976781053 @default.
- W2157844270 cites W1980958926 @default.
- W2157844270 cites W1981898286 @default.
- W2157844270 cites W1992895406 @default.
- W2157844270 cites W1994299057 @default.
- W2157844270 cites W1994905815 @default.
- W2157844270 cites W1997912181 @default.
- W2157844270 cites W1998365428 @default.
- W2157844270 cites W2000898401 @default.
- W2157844270 cites W2002923824 @default.
- W2157844270 cites W2013126973 @default.
- W2157844270 cites W2014935796 @default.
- W2157844270 cites W2019634239 @default.
- W2157844270 cites W2019827914 @default.
- W2157844270 cites W2021584737 @default.
- W2157844270 cites W2023112637 @default.
- W2157844270 cites W2025790672 @default.
- W2157844270 cites W2029739184 @default.
- W2157844270 cites W2031259372 @default.
- W2157844270 cites W2032725114 @default.
- W2157844270 cites W2033955633 @default.
- W2157844270 cites W2035348850 @default.
- W2157844270 cites W2038499023 @default.
- W2157844270 cites W2039557494 @default.
- W2157844270 cites W2057050837 @default.
- W2157844270 cites W2066194444 @default.
- W2157844270 cites W2072765495 @default.
- W2157844270 cites W2077597259 @default.
- W2157844270 cites W2084341282 @default.
- W2157844270 cites W2086093927 @default.
- W2157844270 cites W2088120545 @default.
- W2157844270 cites W2088244436 @default.
- W2157844270 cites W2090020776 @default.
- W2157844270 cites W2091298617 @default.
- W2157844270 cites W2091760375 @default.
- W2157844270 cites W2091941502 @default.
- W2157844270 cites W2092133045 @default.
- W2157844270 cites W2094424127 @default.
- W2157844270 cites W2096000660 @default.
- W2157844270 cites W2100455164 @default.
- W2157844270 cites W2103537403 @default.
- W2157844270 cites W2103583482 @default.
- W2157844270 cites W2105063553 @default.
- W2157844270 cites W2109575852 @default.
- W2157844270 cites W2113215726 @default.
- W2157844270 cites W2113300574 @default.
- W2157844270 cites W2115833116 @default.
- W2157844270 cites W2125349610 @default.
- W2157844270 cites W2132094475 @default.
- W2157844270 cites W2135813503 @default.
- W2157844270 cites W2137119026 @default.
- W2157844270 cites W2140146453 @default.
- W2157844270 cites W2141568746 @default.
- W2157844270 cites W2147238900 @default.
- W2157844270 cites W2153649171 @default.
- W2157844270 cites W2154330374 @default.
- W2157844270 cites W2276715922 @default.
- W2157844270 cites W2321930067 @default.
- W2157844270 cites W2327653911 @default.
- W2157844270 cites W2335597575 @default.
- W2157844270 cites W4251006502 @default.
- W2157844270 cites W93805588 @default.
- W2157844270 doi "https://doi.org/10.1096/fj.12-209304" @default.
- W2157844270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3509061" @default.
- W2157844270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22942074" @default.
- W2157844270 hasPublicationYear "2012" @default.
- W2157844270 type Work @default.
- W2157844270 sameAs 2157844270 @default.
- W2157844270 citedByCount "23" @default.
- W2157844270 countsByYear W21578442702013 @default.
- W2157844270 countsByYear W21578442702014 @default.
- W2157844270 countsByYear W21578442702015 @default.
- W2157844270 countsByYear W21578442702016 @default.
- W2157844270 countsByYear W21578442702017 @default.
- W2157844270 countsByYear W21578442702018 @default.
- W2157844270 countsByYear W21578442702019 @default.
- W2157844270 countsByYear W21578442702020 @default.
- W2157844270 countsByYear W21578442702021 @default.
- W2157844270 countsByYear W21578442702023 @default.