FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157868064> ?p ?o ?g. }

• W2157868064 endingPage "9" @default.
• W2157868064 startingPage "9" @default.
• W2157868064 abstract "MicroRNAs (miRNAs), a class of highly conserved small non-coding RNA molecules, are known to play essential roles in central nervous system (CNS) by causing post-transcriptional gene silencing. There is much evidence that miRNAs have specific temporal and spatial expression patterns in the mammal brain, but little is known about the role of the region specificity for the gene regulatory networks of the brain. This study represents the first attempt to perform a profiling analysis of the differential expression of miRNAs between hippocampus and the Marginal division (MrD) of the neostriatum in the rat brain. Microarray was used to detect the expression of 357 miRNAs in hippocampus and the MrD from three rats. A short-list of the most dysregulated 30 miRNAs per rat was generated for data analysis, and the miRNAs that were represented in two or three short-lists were then further analyzed. Quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) was employed to validate the aberrantly expressed miRNAs obtained from the miRNA microarray analysis. A family of 11 miRNAs demonstrated differential expression between the MrD and hippocampus in more than one rat. Amongst these, miR-383 was differentially expressed in all three rats and up-regulated to the largest degree in rat one, and the ten other miRNAs, let-7d*, miR-181b, miR-187, miR-195, miR-214, miR-382, miR-411, miR-466b, miR-592 and miR-1224 were differentially expressed in at least two rats. Of these ten, besides miR-382 and miR-411 which were up-regulated in one rat and down-regulated in another, the other eight miRNAs retained a uniform direction of regulation (up-regulation or down-regulation) between different specimens. When further examined by RT-PCR, the aberrantly expressed miRNAs, except miR-383 and let-7d*, demonstrated differential expression that significantly correlated with the microarray findings. This study reported that the miRNA expression patterns in MrD was distinct from that of Hip, suggesting the role of miRNAs in the learning and memory function of the MrD probably different from hippocampus." @default.
• W2157868064 created "2016-06-24" @default.
• W2157868064 creator A5007737148 @default.
• W2157868064 creator A5013157565 @default.
• W2157868064 creator A5027834918 @default.
• W2157868064 creator A5035108007 @default.
• W2157868064 creator A5042264451 @default.
• W2157868064 creator A5053323908 @default.
• W2157868064 creator A5063953679 @default.
• W2157868064 creator A5070931994 @default.
• W2157868064 date "2013-01-01" @default.
• W2157868064 modified "2023-10-14" @default.
• W2157868064 title "Comparison of microRNA expression in hippocampus and the marginal division (MrD) of the neostriatum in rats" @default.
• W2157868064 cites W125185122 @default.
• W2157868064 cites W144423133 @default.
• W2157868064 cites W1588326306 @default.
• W2157868064 cites W1920303762 @default.
• W2157868064 cites W1964628768 @default.
• W2157868064 cites W1968300632 @default.
• W2157868064 cites W1978951493 @default.
• W2157868064 cites W2004308806 @default.
• W2157868064 cites W2010691740 @default.
• W2157868064 cites W2013737463 @default.
• W2157868064 cites W2015393978 @default.
• W2157868064 cites W2016683910 @default.
• W2157868064 cites W2018192777 @default.
• W2157868064 cites W2019028138 @default.
• W2157868064 cites W2022230607 @default.
• W2157868064 cites W2026508704 @default.
• W2157868064 cites W2027873044 @default.
• W2157868064 cites W2031268387 @default.
• W2157868064 cites W2033618199 @default.
• W2157868064 cites W2038589902 @default.
• W2157868064 cites W2039141906 @default.
• W2157868064 cites W2050488165 @default.
• W2157868064 cites W2053978557 @default.
• W2157868064 cites W2059222949 @default.
• W2157868064 cites W2059345414 @default.
• W2157868064 cites W2063674195 @default.
• W2157868064 cites W2065608765 @default.
• W2157868064 cites W2071925802 @default.
• W2157868064 cites W2090183355 @default.
• W2157868064 cites W2093683161 @default.
• W2157868064 cites W2096304780 @default.
• W2157868064 cites W2100358595 @default.
• W2157868064 cites W2117802141 @default.
• W2157868064 cites W2120821369 @default.
• W2157868064 cites W2130809733 @default.
• W2157868064 cites W2135920287 @default.
• W2157868064 cites W2138473891 @default.
• W2157868064 cites W2138664009 @default.
• W2157868064 cites W2141792156 @default.
• W2157868064 cites W2149146453 @default.
• W2157868064 cites W2151643998 @default.
• W2157868064 cites W2152804040 @default.
• W2157868064 cites W2159793493 @default.
• W2157868064 cites W2161272397 @default.
• W2157868064 cites W2162674813 @default.
• W2157868064 cites W2162983737 @default.
• W2157868064 doi "https://doi.org/10.1186/1423-0127-20-9" @default.
• W2157868064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3615960" @default.
• W2157868064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23425148" @default.
• W2157868064 hasPublicationYear "2013" @default.
• W2157868064 type Work @default.
• W2157868064 sameAs 2157868064 @default.
• W2157868064 citedByCount "19" @default.
• W2157868064 countsByYear W21578680642014 @default.
• W2157868064 countsByYear W21578680642015 @default.
• W2157868064 countsByYear W21578680642016 @default.
• W2157868064 countsByYear W21578680642018 @default.
• W2157868064 countsByYear W21578680642019 @default.
• W2157868064 countsByYear W21578680642020 @default.
• W2157868064 countsByYear W21578680642021 @default.
• W2157868064 countsByYear W21578680642022 @default.
• W2157868064 crossrefType "journal-article" @default.
• W2157868064 hasAuthorship W2157868064A5007737148 @default.
• W2157868064 hasAuthorship W2157868064A5013157565 @default.
• W2157868064 hasAuthorship W2157868064A5027834918 @default.
• W2157868064 hasAuthorship W2157868064A5035108007 @default.
• W2157868064 hasAuthorship W2157868064A5042264451 @default.
• W2157868064 hasAuthorship W2157868064A5053323908 @default.
• W2157868064 hasAuthorship W2157868064A5063953679 @default.
• W2157868064 hasAuthorship W2157868064A5070931994 @default.
• W2157868064 hasBestOaLocation W21578680641 @default.
• W2157868064 hasConcept C104317684 @default.
• W2157868064 hasConcept C119056186 @default.
• W2157868064 hasConcept C145059251 @default.
• W2157868064 hasConcept C150194340 @default.
• W2157868064 hasConcept C18431079 @default.
• W2157868064 hasConcept C186836561 @default.
• W2157868064 hasConcept C54355233 @default.
• W2157868064 hasConcept C70721500 @default.
• W2157868064 hasConcept C8415881 @default.
• W2157868064 hasConcept C86803240 @default.
• W2157868064 hasConceptScore W2157868064C104317684 @default.
• W2157868064 hasConceptScore W2157868064C119056186 @default.
• W2157868064 hasConceptScore W2157868064C145059251 @default.
• W2157868064 hasConceptScore W2157868064C150194340 @default.

• next