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- W2157880285 abstract "Volumetric muscle loss (VML) is a disabling condition in which current clinical procedures are suboptimal. The field of tissue engineering has many promising strategies for the creation of functional skeletal muscle in vitro. However, there are still two key limitations that prevent it from becoming a solution for treating VML. First, engineered muscle tissue must be biocompatible to facilitate muscle tissue regrowth without generating an immune response. Second, engineered muscle constructs must be scaled up to facilitate replacement of clinically relevant volumes of tissue (centimeters in diameter). There are currently no tissue engineering strategies to produce tissue constructs that are both biocompatible and large enough to facilitate clinical repair. However, recent advances in tissue engineering using synthetic scaffolds, native scaffolds, or scaffold-free approaches may lead to a solution for repair of VML injuries." @default.
- W2157880285 created "2016-06-24" @default.
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- W2157880285 creator A5030222850 @default.
- W2157880285 creator A5030290479 @default.
- W2157880285 creator A5041381155 @default.
- W2157880285 date "2014-01-01" @default.
- W2157880285 modified "2023-09-30" @default.
- W2157880285 title "Engineering muscle constructs for the creation of functional engineered musculoskeletal tissue" @default.
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- W2157880285 doi "https://doi.org/10.2217/rme.13.81" @default.
- W2157880285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4482104" @default.
- W2157880285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24351009" @default.
- W2157880285 hasPublicationYear "2014" @default.
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