FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2157909882> ?p ?o ?g. }

• W2157909882 endingPage "54" @default.
• W2157909882 startingPage "45" @default.
• W2157909882 abstract "Skeletal unloading leads to decreased bone formation and decreased bone mass. Bone resorption is uncoupled from bone formation, contributing to the bone loss. During space flight bone is lost principally from the bones most loaded in the 1 g environment. Determining the mechanism(s) by which loading of bone is sensed and translated into a signal(s) controlling bone formation remains the holy grail in this field. It seems likely that matrix/cell interactions will underlie much of the mechanocoupling. Integrins are a prime mediator of such interactions. The role for systemic hormones such as PTH, GH and 1,25(OH)2D compared to locally produced factors such as IGF-I, PTHrP, BMPs and TGF beta in modulating the cellular response to load remains unclear. Our studies demonstrate that skeletal unloading leads to resistance to the anabolic actions of IGF-I on bone as a result of failure of IGF-I to activate its own signaling pathways. This is associated with a reduction in integrin expression, suggesting crosstalk between these two pathways. As the mechanism(s) by which bone responds to changes in mechanical load with changes in bone formation is further elucidated, applications of this knowledge to other etiologies of osteoporosis are likely to develop. Skeletal unloading provides a perturbation in bone mineral homeostasis that can be used to understand the mechanisms by which bone mineral homeostasis is maintained, and that such understanding will lead to effective treatment for disuse osteoporosis in addition to preventive measures for the bone loss that accompanies space travel." @default.
• W2157909882 created "2016-06-24" @default.
• W2157909882 creator A5032781101 @default.
• W2157909882 creator A5062591890 @default.
• W2157909882 creator A5083726183 @default.
• W2157909882 date "2003-06-01" @default.
• W2157909882 modified "2023-10-17" @default.
• W2157909882 title "The impact of skeletal unloading on bone formation." @default.
• W2157909882 cites W1530134588 @default.
• W2157909882 cites W1565135627 @default.
• W2157909882 cites W1718909266 @default.
• W2157909882 cites W174716201 @default.
• W2157909882 cites W1759177456 @default.
• W2157909882 cites W1808022671 @default.
• W2157909882 cites W1856706118 @default.
• W2157909882 cites W1877825263 @default.
• W2157909882 cites W1884487838 @default.
• W2157909882 cites W1891934671 @default.
• W2157909882 cites W1899220681 @default.
• W2157909882 cites W1910347656 @default.
• W2157909882 cites W1927799846 @default.
• W2157909882 cites W1946664585 @default.
• W2157909882 cites W1963201824 @default.
• W2157909882 cites W1963675144 @default.
• W2157909882 cites W1968738869 @default.
• W2157909882 cites W1968814931 @default.
• W2157909882 cites W1977847967 @default.
• W2157909882 cites W1980155309 @default.
• W2157909882 cites W1981791036 @default.
• W2157909882 cites W1983023085 @default.
• W2157909882 cites W1992460009 @default.
• W2157909882 cites W1992764172 @default.
• W2157909882 cites W2000231768 @default.
• W2157909882 cites W2003482365 @default.
• W2157909882 cites W2008087136 @default.
• W2157909882 cites W2013271696 @default.
• W2157909882 cites W2015138949 @default.
• W2157909882 cites W2017719396 @default.
• W2157909882 cites W2017949036 @default.
• W2157909882 cites W2023293227 @default.
• W2157909882 cites W2023876930 @default.
• W2157909882 cites W2025734362 @default.
• W2157909882 cites W2025831864 @default.
• W2157909882 cites W2031939534 @default.
• W2157909882 cites W2038964866 @default.
• W2157909882 cites W2039825798 @default.
• W2157909882 cites W2044677269 @default.
• W2157909882 cites W2044782892 @default.
• W2157909882 cites W2047065962 @default.
• W2157909882 cites W2048912306 @default.
• W2157909882 cites W2050518965 @default.
• W2157909882 cites W2052055923 @default.
• W2157909882 cites W2055658787 @default.
• W2157909882 cites W2065445579 @default.
• W2157909882 cites W2080590083 @default.
• W2157909882 cites W2083088963 @default.
• W2157909882 cites W2083434885 @default.
• W2157909882 cites W2090241995 @default.
• W2157909882 cites W2091643005 @default.
• W2157909882 cites W2102303758 @default.
• W2157909882 cites W2111673027 @default.
• W2157909882 cites W2111925745 @default.
• W2157909882 cites W2133664160 @default.
• W2157909882 cites W2148831748 @default.
• W2157909882 cites W2152702648 @default.
• W2157909882 cites W2159621404 @default.
• W2157909882 cites W2186181194 @default.
• W2157909882 cites W2188859325 @default.
• W2157909882 cites W2189587829 @default.
• W2157909882 cites W2231105542 @default.
• W2157909882 cites W2312380669 @default.
• W2157909882 cites W2340257712 @default.
• W2157909882 cites W2400294607 @default.
• W2157909882 cites W2408993738 @default.
• W2157909882 cites W2411920287 @default.
• W2157909882 cites W2422495554 @default.
• W2157909882 cites W2424164331 @default.
• W2157909882 cites W2607429329 @default.
• W2157909882 cites W3181828566 @default.
• W2157909882 cites W329954952 @default.
• W2157909882 cites W393228535 @default.
• W2157909882 cites W94140509 @default.
• W2157909882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12959131" @default.
• W2157909882 hasPublicationYear "2003" @default.
• W2157909882 type Work @default.
• W2157909882 sameAs 2157909882 @default.
• W2157909882 citedByCount "52" @default.
• W2157909882 countsByYear W21579098822012 @default.
• W2157909882 countsByYear W21579098822013 @default.
• W2157909882 countsByYear W21579098822014 @default.
• W2157909882 countsByYear W21579098822015 @default.
• W2157909882 countsByYear W21579098822016 @default.
• W2157909882 countsByYear W21579098822018 @default.
• W2157909882 countsByYear W21579098822019 @default.
• W2157909882 countsByYear W21579098822020 @default.
• W2157909882 countsByYear W21579098822022 @default.
• W2157909882 countsByYear W21579098822023 @default.
• W2157909882 crossrefType "journal-article" @default.

• next