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• W2157966641 abstract "Recent reports suggested involvement of mitogen-activated protein (MAP) kinases in the pathogenesis of Shiga toxin-induced hemolytic uremic syndrome (HUS). In the present study, we investigated a role for subtilase cytotoxin (SubAB), a possible trigger for HUS, in the regulation of MAP kinases. Treatment of cells with SubAB caused phosphorylation of c-Jun NH(2)-terminal kinase, extracellular signal-regulated kinase (ERK), and p38 MAP kinase. It was associated with activation of activator protein 1 (AP-1) and induction of AP-1-dependent transcription. SubAB induced the unfolded protein response (UPR) and consequently caused MAP kinase activation. SubAB led to induction of three major branches of the UPR, and the protein kinase-like endoplasmic reticulum kinase and inositol-requiring ER-to-nucleus signal kinase 1 pathways were responsible for the activation of MAP kinases. These results elucidated the potential of SubAB to trigger MAP kinase pathways via the UPR, which may contribute to the pathogenesis of Shiga toxin-induced HUS." @default.
• W2157966641 created "2016-06-24" @default.
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• W2157966641 date "2010-12-08" @default.
• W2157966641 modified "2023-09-23" @default.
• W2157966641 title "Subtilase Cytotoxin Activates MAP Kinases through PERK and IRE1 Branches of the Unfolded Protein Response" @default.
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• W2157966641 doi "https://doi.org/10.1093/toxsci/kfq368" @default.
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