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• W2157973417 abstract "No AccessJournal of UrologyAdult urology1 Aug 2007The Contribution of Common Medical Conditions and Drug Exposures to Erectile Dysfunction in Adult Males Mildred E. Francis, John W. Kusek, Leroy M. Nyberg, and Paul W. Eggers Mildred E. FrancisMildred E. Francis Social & Scientific Systems Inc., Silver Spring, Maryland Supported by a National Institute of Diabetes and Digestive and Kidney Diseases contract (#N001-DK-1-2478). More articles by this author , John W. KusekJohn W. Kusek Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland More articles by this author , Leroy M. NybergLeroy M. Nyberg Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland More articles by this author , and Paul W. EggersPaul W. Eggers Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2007.03.127AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We examined the association of prevalent erectile dysfunction and coexisting medical conditions in United States men taking into account age and drug exposures. Materials and Methods: Men older than 40 years who participated in the 2001 to 2002 National Health and Nutrition Examination Survey were asked to report on erectile function. Men who were never able to achieve an erection sufficient for intercourse were defined as having complete erectile dysfunction. Adjusted odds ratios for complete erectile dysfunction prevalence in men with a coexisting condition compared to those without the condition were calculated. Age, race/ethnicity, urinary symptoms, cardiovascular disease, diabetes, hypertension with and without selected antihypertensive therapy (mainly beta blockers and thiazide diuretics), selected antidepressant therapy (mainly, tricyclics and selective serotonin reuptake inhibitors), smoking and alcohol were included in all statistical models. Results: Of United States men 8% (95% CI 6.0–10.2) reported complete erectile dysfunction. In multivariate analyses, obstructive urinary symptoms (OR 2.0, 95% CI 1.2–3.4), diabetes (OR 2.6, 95% CI 1.3–5.2), hypertension with selected antihypertensive therapy (OR 3.0, 95% CI 1.6–5.9), and selected antidepressant therapy (OR 5.2, 95% CI 1.7–15.9), increased the odds of complete erectile dysfunction prevalence, whereas presence of cardiovascular disease, urinary incontinence and hypertension without selected antihypertensive therapy did not. Conclusions: Obstructive urinary symptoms, diabetes, hypertension treated with selected medications, and selected antidepressant drug use are independently associated with increased erectile dysfunction risk in United States men. Physicians should carefully consider the potential impact of these medications and comorbid conditions when discussing sexual function with their male patients. References 1 : Drug-related erectile dysfunction. Adverse Drug React Toxicol Rev1999; 18: 5. Google Scholar 2 : Erectile dysfunction. 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Google Scholar 10 : A new surrogate variable for erectile dysfunction status in the Massachusetts male aging study. J Clin Epidemiol2000; 53: 71. Google Scholar 11 : Sexual function in men older than 50 years of age: results from the Health Professionals Follow-up Study. Ann Intern Med2003; 139: 161. Google Scholar 12 : Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire. Eur Urol2005; 47: 80. Google Scholar 13 : Plan and operation of the Third National Health and Nutrition Examination Survey, 1988–94. Vital Health Stat1994; 1: 94. Google Scholar 14 : Sexual function of men ages 40 to 79 years: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. J Am Geriatr Soc1995; 43: 1107. Google Scholar 15 : Association between lower urinary tract symptoms and erectile dysfunction. Urology2004; 64: 772. Google Scholar 16 : The relationship between erectile dysfunction and lower urinary tract symptoms: epidemiological, clinical, and basic science evidence. Curr Urol Rep2004; 5: 251. Google Scholar 17 : Erectile dysfunction as a predictor of the metabolic syndrome in aging men: results from the Massachusetts Male Aging Study. J Urol2006; 176: 222. Link, Google Scholar 18 : NIH Consensus Conference: Impotence. JAMA1993; 270: 83. Google Scholar 19 : The validity of a single-question self-report of erectile dysfunction. J Gen Intern Med2005; 20: 515. Google Scholar © 2007 by American Urological AssociationFiguresReferencesRelatedDetailsCited byCalzo J, Austin S, Charlton B, Missmer S, Kathrins M, Gaskins A and Chavarro J (2020) Erectile Dysfunction in a Sample of Sexually Active Young Adult Men from a U.S. Cohort: Demographic, Metabolic and Mental Health CorrelatesJournal of Urology, VOL. 205, NO. 2, (539-544), Online publication date: 1-Feb-2021. Volume 178Issue 2August 2007Page: 591-596 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsdrugperscriptionshealth surveysimpotencecomorbidityMetricsAuthor Information Mildred E. Francis Social & Scientific Systems Inc., Silver Spring, Maryland Supported by a National Institute of Diabetes and Digestive and Kidney Diseases contract (#N001-DK-1-2478). More articles by this author John W. Kusek Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland More articles by this author Leroy M. Nyberg Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland More articles by this author Paul W. Eggers Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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