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- W2157996819 abstract "The avirulent Salmonella typhimurium F885 was transformed with a plasmid carrying the cloned S fimbriae genes of a uropathogenic Escherichia coli. The resulting transformant (F885-1) produced efficiently E. coli S fimbriae and was used for live oral vaccination of rats. For comparison rats were immunized subcutaneously with isolated S fimbriae. Both routes of vaccination resulted in a significant IgG antibody response to S fimbriae. In addition live oral vaccination induced a serum IgA response against S fimbriae. After transurethral infection of rats with a S fimbriae producing E. coli a 10-fold reduction of bacterial counts in the kidney was observed in rats orally vaccinated with F885-1 as compared to unvaccinated controls. This study suggests that the avirulent Salmonella F885 may be used as a fimbrial antigen carrier for oral vaccination against renal infections." @default.
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- W2157996819 date "1989-03-01" @default.
- W2157996819 modified "2023-10-14" @default.
- W2157996819 title "Oral vaccination of rats with live avirulentSalmonelladerivatives expressing adhesive fimbrial antigens of uropathogenicEscherichia coli" @default.
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- W2157996819 doi "https://doi.org/10.1111/j.1574-6968.1989.tb02387.x" @default.
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