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• W2158002582 endingPage "1989" @default.
• W2158002582 startingPage "1980" @default.
• W2158002582 abstract "ABSTRACT Epstein-Barr virus (EBV), the only known human lymphocryptovirus (LCV), displays a remarkable degree of genetic and biologic identity to LCVs that infect Old World primates. Within their natural hosts, infection by these viruses recapitulates many key aspects of EBV infection, including the establishment of long-term latency within B lymphocytes, and is therefore a potentially valuable animal model of EBV infection. However, it is unclear whether these LCVs have adopted or maintained the same mechanisms used by EBV to express essential viral proteins, such as EBNA-1, in the face of cell-mediated repression of EBV gene expression that occurs upon establishment of the asymptomatic carrier state. To address this issue, we determined whether the endogenous LCVs of baboon (Cercopithecine herpesvirus 12) and rhesus macaque (Cercopithecine herpesvirus 15) have the functional equivalent of the EBV promoter Qp, which mediates exclusive expression of EBNA-1 during the restricted programs of EBV latency associated with the carrier state. Our results indicate that (i) both the baboon and rhesus macaque LCVs have a genomic locus that is highly homologous to the EBV Qp region, (ii) key cis -regulatory elements of Qp are conserved in these LCV genomes and compose promoters that are functionally indistinguishable from EBV Qp, and (iii) EBNA-1 transcripts identical in structure to EBV Qp-specific EBNA-1 mRNAs are present in nonhuman LCV-infected cells, demonstrating that these Qp homologs are indeed utilized as alternative EBNA-1 promoters. These observations indicate that the molecular mechanisms which regulate EBV gene expression during restricted latency have been conserved among the LCVs. The contribution of these mechanisms to viral persistence in vivo can now be experimentally tested in nonhuman primate models of LCV infection." @default.
• W2158002582 created "2016-06-24" @default.
• W2158002582 creator A5050601405 @default.
• W2158002582 creator A5052033267 @default.
• W2158002582 creator A5071880720 @default.
• W2158002582 creator A5082182067 @default.
• W2158002582 date "1999-03-01" @default.
• W2158002582 modified "2023-10-16" @default.
• W2158002582 title "Mechanisms That Regulate Epstein-Barr Virus EBNA-1 Gene Transcription during Restricted Latency Are Conserved among Lymphocryptoviruses of Old World Primates" @default.
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• W2158002582 doi "https://doi.org/10.1128/jvi.73.3.1980-1989.1999" @default.
• W2158002582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104440" @default.
• W2158002582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9971778" @default.
• W2158002582 hasPublicationYear "1999" @default.
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• W2158002582 hasAuthorship W2158002582A5052033267 @default.
• W2158002582 hasAuthorship W2158002582A5071880720 @default.

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