FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158026056> ?p ?o ?g. }

• W2158026056 abstract "The t(9;22)(q34;q11) or Philadelphia chromosome that creates a BCR-ABL1 fusion gene encoding for a chimeric BCR-ABL1 protein is present in 3-4% of pediatric acute lymphoblastic leukemia (Ph+ ALL), and about 25% of adult ALL cases. Prior to the advent of tyrosine kinase inhibitors (TKI), Ph+ ALL was associated with a very poor prognosis despite use of intensive chemotherapy and frequently hematopoietic stem cell transplantation (HSCT) in first remission. The development of TKIs revolutionized the therapy of Ph+ ALL. Addition of the first generation ABL1 class TKI imatinib to intensive chemotherapy dramatically increased survival for children with Ph+ ALL and established that many patients can be cured without HSCT. In parallel, the mechanistic understanding of Ph+ ALL expanded exponentially through careful mapping of pathways downstream of BCR-ABL1, the discovery of mutations in master regulators of B-cell development such as IKZF1 (Ikaros), PAX5 and EBF, the recognition of the complex clonal architecture of Ph+ ALL, and the delineation of genomic, epigenetic and signaling abnormalities contributing to relapse and resistance. Still, many important basic and clinical questions remain unanswered. Current clinical trials are testing second generation TKIs in patients with newly diagnosed Ph+ ALL. Neither the optimal duration of therapy nor the optimal chemotherapy backbone are currently defined. The role of HSCT in first remission and post-transplant TKI therapy also require further study. In addition, it will be crucial to continue to dig deeper into understanding Ph+ ALL at a mechanistic level, and translate findings into complementary targeted approaches. Expanding targeted therapies holds great promise to decrease toxicity and improve survival in this high risk disease, which provides a paradigm for how targeted therapies can be incorporated into treatment of other high risk leukemias." @default.
• W2158026056 created "2016-06-24" @default.
• W2158026056 creator A5023214494 @default.
• W2158026056 creator A5061325882 @default.
• W2158026056 date "2014-03-25" @default.
• W2158026056 modified "2023-10-15" @default.
• W2158026056 title "Current Concepts in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia" @default.
• W2158026056 cites W1481473039 @default.
• W2158026056 cites W1514944406 @default.
• W2158026056 cites W1522335697 @default.
• W2158026056 cites W1532255091 @default.
• W2158026056 cites W1765454988 @default.
• W2158026056 cites W1775608294 @default.
• W2158026056 cites W1806826967 @default.
• W2158026056 cites W1963918680 @default.
• W2158026056 cites W1964151035 @default.
• W2158026056 cites W1965264462 @default.
• W2158026056 cites W1966989024 @default.
• W2158026056 cites W1967037503 @default.
• W2158026056 cites W1967358345 @default.
• W2158026056 cites W1968071128 @default.
• W2158026056 cites W1970135399 @default.
• W2158026056 cites W1970154345 @default.
• W2158026056 cites W1971273349 @default.
• W2158026056 cites W1971894480 @default.
• W2158026056 cites W1972804480 @default.
• W2158026056 cites W1973607853 @default.
• W2158026056 cites W1973720500 @default.
• W2158026056 cites W1974195879 @default.
• W2158026056 cites W1975932664 @default.
• W2158026056 cites W1976482378 @default.
• W2158026056 cites W1978777017 @default.
• W2158026056 cites W1980528362 @default.
• W2158026056 cites W1980590401 @default.
• W2158026056 cites W1982798544 @default.
• W2158026056 cites W1983393070 @default.
• W2158026056 cites W1984065010 @default.
• W2158026056 cites W1984684983 @default.
• W2158026056 cites W1984771935 @default.
• W2158026056 cites W1984879354 @default.
• W2158026056 cites W1984948591 @default.
• W2158026056 cites W1985439299 @default.
• W2158026056 cites W1986263057 @default.
• W2158026056 cites W1986500198 @default.
• W2158026056 cites W1987895181 @default.
• W2158026056 cites W1988377311 @default.
• W2158026056 cites W1989645452 @default.
• W2158026056 cites W1993648538 @default.
• W2158026056 cites W1993808217 @default.
• W2158026056 cites W1994568187 @default.
• W2158026056 cites W1994721658 @default.
• W2158026056 cites W1995289294 @default.
• W2158026056 cites W1995552866 @default.
• W2158026056 cites W1996697756 @default.
• W2158026056 cites W1997360163 @default.
• W2158026056 cites W1998593414 @default.
• W2158026056 cites W1998823290 @default.
• W2158026056 cites W2000116184 @default.
• W2158026056 cites W2000918094 @default.
• W2158026056 cites W2001388714 @default.
• W2158026056 cites W2002213310 @default.
• W2158026056 cites W2004368096 @default.
• W2158026056 cites W2008271309 @default.
• W2158026056 cites W2013975022 @default.
• W2158026056 cites W2013994599 @default.
• W2158026056 cites W2015561372 @default.
• W2158026056 cites W2016086822 @default.
• W2158026056 cites W2016749216 @default.
• W2158026056 cites W2017580443 @default.
• W2158026056 cites W2018796139 @default.
• W2158026056 cites W2019300684 @default.
• W2158026056 cites W2019591833 @default.
• W2158026056 cites W2021050536 @default.
• W2158026056 cites W2021193366 @default.
• W2158026056 cites W2021687581 @default.
• W2158026056 cites W2023902191 @default.
• W2158026056 cites W2024352108 @default.
• W2158026056 cites W2025696725 @default.
• W2158026056 cites W2025950197 @default.
• W2158026056 cites W2026085183 @default.
• W2158026056 cites W2027847241 @default.
• W2158026056 cites W2028104399 @default.
• W2158026056 cites W2028111305 @default.
• W2158026056 cites W2028959752 @default.
• W2158026056 cites W2029295385 @default.
• W2158026056 cites W2033790900 @default.
• W2158026056 cites W2034115103 @default.
• W2158026056 cites W2034200430 @default.
• W2158026056 cites W2034648832 @default.
• W2158026056 cites W2035502959 @default.
• W2158026056 cites W2035910722 @default.
• W2158026056 cites W2036158456 @default.
• W2158026056 cites W2036599257 @default.
• W2158026056 cites W2037104393 @default.
• W2158026056 cites W2037154482 @default.
• W2158026056 cites W2038403427 @default.
• W2158026056 cites W2039201527 @default.
• W2158026056 cites W2039787365 @default.
• W2158026056 cites W2040329520 @default.
• W2158026056 cites W2040396943 @default.

• next