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- W2158038784 abstract "Indoleamine 2,3-dioxygenase (IDO) is an interferon (IFN)-gamma-inducible, extrahepatic enzyme that catalyses the initial and rate-limiting step in the degradation of the essential amino acid tryptophan. Elevated tryptophan catabolism mediated by IDO is associated with a wide variety of human cancers and has historically been thought to be a tumoricidal consequence of IFN-gamma exposure. Evidence of a physiological requirement for IDO activity in protecting the allogeneic fetus from rejection by the maternal immune system has stimulated a radical shift in thinking about the role of IDO in cancer. Evidence now suggests that tumours can exploit IDO-mediated peripheral tolerance to promote immune escape. This review summarises key studies that implicate IDO as an important mediator of peripheral immune tolerance as well as the development of a promising new anticancer modality that incorporates the use of IDO inhibitors. The second part focuses on the current state of development of IDO inhibitory compounds as potential pharmaceutical agents." @default.
- W2158038784 created "2016-06-24" @default.
- W2158038784 creator A5026984771 @default.
- W2158038784 creator A5063480688 @default.
- W2158038784 creator A5089381889 @default.
- W2158038784 date "2005-08-01" @default.
- W2158038784 modified "2023-10-18" @default.
- W2158038784 title "Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors" @default.
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- W2158038784 doi "https://doi.org/10.1517/14728222.9.4.831" @default.
- W2158038784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16083346" @default.
- W2158038784 hasPublicationYear "2005" @default.
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