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• W2158045389 startingPage "1891" @default.
• W2158045389 abstract "Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes major epidemics of rash, fever, and debilitating arthritis. Currently, there are no vaccines or antivirals available for prevention or treatment. We therefore generated 2 live-attenuated vaccine candidates based on the insertion of a picornavirus internal ribosome entry site (IRES) sequence into the genome of CHIKV. Vaccination of cynomolgus macaques with a single dose of either vaccine produced no signs of disease but was highly immunogenic. After challenge with a subcutaneous inoculation of wild-type CHIKV, both vaccine candidates prevented the development of detectable viremia. Protected animals also exhibited no significant changes in core body temperature or cardiovascular rhythm, whereas sham-vaccinated animals showed hyperthermia, followed by sustained hypothermia, as well as significant changes in heart rate. These CHIKV/IRES vaccine candidates appear to be safe and efficacious, supporting their strong potential as human vaccines to protect against CHIKV infection and reduce transmission and further spread." @default.
• W2158045389 created "2016-06-24" @default.
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• W2158045389 date "2014-01-07" @default.
• W2158045389 modified "2023-10-16" @default.
• W2158045389 title "Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose" @default.
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• W2158045389 doi "https://doi.org/10.1093/infdis/jiu014" @default.
• W2158045389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4038141" @default.
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• W2158045389 hasPublicationYear "2014" @default.
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