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• W2158045551 abstract "Abstract Interleukin-15 (IL-15) is a proinflammatory cytokine involved in the development, survival, proliferation, and activation of multiple lymphocyte lineages utilizing a variety of signaling pathways. IL-15 utilizes three distinct receptor chains in at least two different combinations to signal and exert its effects on the immune system. The binding of IL-15 to its receptor complex activates an “immune-enhancing” signaling cascade in natural killer cells and subsets of T cells, as well as the induction of a number of proto-oncogenes. Additional studies have explored the role of IL-15 in the development and progression of cancer, notably leukemia of large granular lymphocytes, cutaneous T-cell lymphoma, and multiple myeloma. This review provides an overview of the molecular events in the IL-15 signaling pathway and the aberrancies in its regulation that are associated with chronic inflammation and cancer. We briefly explore the potential therapeutic opportunities that have arisen as a result of these studies to further the treatment of cancer. These involve both targeting the disruption of IL-15 signaling as well as IL-15–mediated enhancement of innate and antigen-specific immunity. Clin Cancer Res; 20(8); 2044–50. ©2014 AACR." @default.
• W2158045551 created "2016-06-24" @default.
• W2158045551 creator A5049192022 @default.
• W2158045551 creator A5063390263 @default.
• W2158045551 creator A5074920328 @default.
• W2158045551 date "2014-04-15" @default.
• W2158045551 modified "2023-10-11" @default.
• W2158045551 title "Molecular Pathways: Interleukin-15 Signaling in Health and in Cancer" @default.
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• W2158045551 doi "https://doi.org/10.1158/1078-0432.ccr-12-3603" @default.
• W2158045551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3989546" @default.
• W2158045551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24737791" @default.
• W2158045551 hasPublicationYear "2014" @default.
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