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• W2158048614 abstract "Stenotrophomonas ssp. has a wide environmental distribution and is also found as an opportunistic pathogen, causing nosocomial or community-acquired infections. One species, S. maltophilia , presents multidrug resistance and has been associated with serious infections in pediatric and immunocompromised patients. Therefore, it is relevant to conduct resistance profile and phylogenetic studies in clinical isolates for identifying infection origins and isolates with augmented pathogenic potential. Here, multilocus sequence typing was performed for phylogenetic analysis of nosocomial isolates of Stenotrophomonas spp. and, environmental and clinical strains of S. maltophilia . Biochemical and multidrug resistance profiles of nosocomial and clinical strains were determined. The inferred phylogenetic profile showed high clonal variability, what correlates with the adaptability process of Stenotrophomonas to different habitats. Two clinical isolates subgroups of S. maltophilia sharing high phylogenetic homogeneity presented intergroup recombination, thus indicating the high permittivity to horizontal gene transfer, a mechanism involved in the acquisition of antibiotic resistance and expression of virulence factors. For most of the clinical strains, phylogenetic inference was made using only partial pps A gene sequence. Therefore, the sequencing of just one specific fragment of this gene would allow, in many cases, determining whether the infection with S. maltophilia was nosocomial or community-acquired." @default.
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• W2158048614 date "2014-01-01" @default.
• W2158048614 modified "2023-10-14" @default.
• W2158048614 title "Phylogenetic Analysis of<i>Stenotrophomonas</i>spp. Isolates Contributes to the Identification of Nosocomial and Community-Acquired Infections" @default.
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• W2158048614 doi "https://doi.org/10.1155/2014/151405" @default.
• W2158048614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4003845" @default.
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