FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158049131> ?p ?o ?g. }

• W2158049131 endingPage "180" @default.
• W2158049131 startingPage "171" @default.
• W2158049131 abstract "Background Inhibition of tumor-induced angiogenesis may restrict tumor growth and metastasis. Long-term systemic delivery of angiogenic inhibitors is associated with toxicity, as well as other severe side-effects. The utility of cells as vehicles for gene therapy to deliver therapeutic molecules has been suggested to represent an efficient approach. Mesenchymal stem cells (MSCs) exhibit a tropism to cancer tissue, and may serve as a cellular delivery vehicle and a local producer of anti-angiogenic agents. Methods In the present study, we attempted to assess production of the transgene, α1-antitrypsin (AAT), in lentivirus-transduced human MSCs and its cytotoxicity against human umbilical cord vein endothelial cells (HUVEC). The secreted protein from these effector cells was determined by an enzyme-linked immunosorbent assay. The cytotoxicity of hMSCs that overexpress the human AAT gene against HUVEC was evaluated with an apoptotic assay. Results Lentivirus-transduced hMSCs produced functional AAT and displayed much higher cytotoxicity against HUVEC than untransduced hMSCs. Moreover, AAT secreted from transduced hMSCs significantly inhibited HUVEC proliferation compared to untransduced hMSCs. The data obtained demonstrate for the first time that genetically modified hMSCs released abundant and functional AAT that caused obvious cytotoxicity to HUVEC. Conclusions hMSC may serve as an effective platform for the targeted delivery of therapeutic proteins to cancer sites. Copyright © 2011 John Wiley & Sons, Ltd." @default.
• W2158049131 created "2016-06-24" @default.
• W2158049131 creator A5023531115 @default.
• W2158049131 creator A5023690834 @default.
• W2158049131 creator A5036284357 @default.
• W2158049131 creator A5050821610 @default.
• W2158049131 creator A5073686280 @default.
• W2158049131 creator A5074024316 @default.
• W2158049131 creator A5088377096 @default.
• W2158049131 date "2011-03-01" @default.
• W2158049131 modified "2023-10-17" @default.
• W2158049131 title "Mesenchymal stem cells as vehicles for targeted delivery of anti-angiogenic protein to solid tumors" @default.
• W2158049131 cites W1502713173 @default.
• W2158049131 cites W1602886012 @default.
• W2158049131 cites W1969005256 @default.
• W2158049131 cites W1982389534 @default.
• W2158049131 cites W2007392553 @default.
• W2158049131 cites W2019023730 @default.
• W2158049131 cites W2022084143 @default.
• W2158049131 cites W2022512688 @default.
• W2158049131 cites W2023703161 @default.
• W2158049131 cites W2061418597 @default.
• W2158049131 cites W2069649414 @default.
• W2158049131 cites W2071743417 @default.
• W2158049131 cites W2074707881 @default.
• W2158049131 cites W2079312847 @default.
• W2158049131 cites W2094155824 @default.
• W2158049131 cites W2101526099 @default.
• W2158049131 cites W2105374622 @default.
• W2158049131 cites W2117603584 @default.
• W2158049131 cites W2120716934 @default.
• W2158049131 cites W2122368175 @default.
• W2158049131 cites W2125793635 @default.
• W2158049131 cites W2135568887 @default.
• W2158049131 cites W2143022774 @default.
• W2158049131 cites W2464262759 @default.
• W2158049131 doi "https://doi.org/10.1002/jgm.1552" @default.
• W2158049131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21449040" @default.
• W2158049131 hasPublicationYear "2011" @default.
• W2158049131 type Work @default.
• W2158049131 sameAs 2158049131 @default.
• W2158049131 citedByCount "35" @default.
• W2158049131 countsByYear W21580491312012 @default.
• W2158049131 countsByYear W21580491312013 @default.
• W2158049131 countsByYear W21580491312014 @default.
• W2158049131 countsByYear W21580491312015 @default.
• W2158049131 countsByYear W21580491312016 @default.
• W2158049131 countsByYear W21580491312017 @default.
• W2158049131 countsByYear W21580491312018 @default.
• W2158049131 countsByYear W21580491312019 @default.
• W2158049131 countsByYear W21580491312020 @default.
• W2158049131 countsByYear W21580491312021 @default.
• W2158049131 countsByYear W21580491312022 @default.
• W2158049131 crossrefType "journal-article" @default.
• W2158049131 hasAuthorship W2158049131A5023531115 @default.
• W2158049131 hasAuthorship W2158049131A5023690834 @default.
• W2158049131 hasAuthorship W2158049131A5036284357 @default.
• W2158049131 hasAuthorship W2158049131A5050821610 @default.
• W2158049131 hasAuthorship W2158049131A5073686280 @default.
• W2158049131 hasAuthorship W2158049131A5074024316 @default.
• W2158049131 hasAuthorship W2158049131A5088377096 @default.
• W2158049131 hasBestOaLocation W21580491312 @default.
• W2158049131 hasConcept C104317684 @default.
• W2158049131 hasConcept C109316439 @default.
• W2158049131 hasConcept C111599444 @default.
• W2158049131 hasConcept C135983454 @default.
• W2158049131 hasConcept C185592680 @default.
• W2158049131 hasConcept C198826908 @default.
• W2158049131 hasConcept C202751555 @default.
• W2158049131 hasConcept C203014093 @default.
• W2158049131 hasConcept C2777411675 @default.
• W2158049131 hasConcept C2780394083 @default.
• W2158049131 hasConcept C28328180 @default.
• W2158049131 hasConcept C502942594 @default.
• W2158049131 hasConcept C55493867 @default.
• W2158049131 hasConcept C86803240 @default.
• W2158049131 hasConcept C95444343 @default.
• W2158049131 hasConceptScore W2158049131C104317684 @default.
• W2158049131 hasConceptScore W2158049131C109316439 @default.
• W2158049131 hasConceptScore W2158049131C111599444 @default.
• W2158049131 hasConceptScore W2158049131C135983454 @default.
• W2158049131 hasConceptScore W2158049131C185592680 @default.
• W2158049131 hasConceptScore W2158049131C198826908 @default.
• W2158049131 hasConceptScore W2158049131C202751555 @default.
• W2158049131 hasConceptScore W2158049131C203014093 @default.
• W2158049131 hasConceptScore W2158049131C2777411675 @default.
• W2158049131 hasConceptScore W2158049131C2780394083 @default.
• W2158049131 hasConceptScore W2158049131C28328180 @default.
• W2158049131 hasConceptScore W2158049131C502942594 @default.
• W2158049131 hasConceptScore W2158049131C55493867 @default.
• W2158049131 hasConceptScore W2158049131C86803240 @default.
• W2158049131 hasConceptScore W2158049131C95444343 @default.
• W2158049131 hasIssue "3" @default.
• W2158049131 hasLocation W21580491311 @default.
• W2158049131 hasLocation W21580491312 @default.
• W2158049131 hasLocation W21580491313 @default.
• W2158049131 hasLocation W21580491314 @default.
• W2158049131 hasOpenAccess W2158049131 @default.

• next