FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158049152> ?p ?o ?g. }

• W2158049152 endingPage "H832" @default.
• W2158049152 startingPage "H825" @default.
• W2158049152 abstract "Previous studies have shown a role for nitric oxide and S-nitrosylation (SNO) in postconditioning (PostC), but specific SNO proteins and sites have not been identified in the myocardium after PostC. In this study, we examined SNO signaling in PostC using a Langendorff-perfused mouse heart model. After 20 min of equilibrium perfusion and 25 min of global ischemia, PostC was applied at the beginning of reperfusion with six cycles of 10 s of reperfusion and 10 s of ischemia. The total period of reperfusion was 90 min. Compared with the ischemia-reperfusion (I/R) control, PostC significantly reduced postischemic contractile dysfunction and infarct size. PostC-induced protection was blocked by treatment with N G -nitro-l-arginine methyl ester (l-NAME) (10 μmol/l; a constitutive NO synthase inhibitor), but not by either ODQ (10 μmol/l, a highly selective soluble guanylyl cyclase inhibitor) or KT5823 (1 μmol/l, a specific protein kinase G inhibitor). Two biotin switch based methods, two dimensional CyDye-maleimide difference gel electrophoresis (2D CyDye-maleimide DIGE) and SNO-resin-assisted capture (SNO-RAC), were utilized to identify SNO-modified proteins and sites. Using 2D CyDye-maleimide DIGE analysis, PostC was found to cause a 25% or greater increase in SNO of a number of proteins, which was blocked by treatment with l-NAME in parallel with the loss of protection. Using SNO-RAC, we identified 77 unique proteins with SNO sites after PostC. These results suggest that NO-mediated SNO signaling is involved in PostC-induced cardioprotection and these data provide the first set of candidate SNO proteins in PostC hearts." @default.
• W2158049152 created "2016-06-24" @default.
• W2158049152 creator A5038709923 @default.
• W2158049152 creator A5064257229 @default.
• W2158049152 creator A5072585999 @default.
• W2158049152 creator A5074883482 @default.
• W2158049152 creator A5077806459 @default.
• W2158049152 creator A5089124744 @default.
• W2158049152 date "2014-03-15" @default.
• W2158049152 modified "2023-09-23" @default.
• W2158049152 title "Postconditioning leads to an increase in protein <i>S</i>-nitrosylation" @default.
• W2158049152 cites W144499510 @default.
• W2158049152 cites W1757182810 @default.
• W2158049152 cites W1964437006 @default.
• W2158049152 cites W1968317652 @default.
• W2158049152 cites W1978939159 @default.
• W2158049152 cites W1982607624 @default.
• W2158049152 cites W1991454533 @default.
• W2158049152 cites W1991627669 @default.
• W2158049152 cites W1992254322 @default.
• W2158049152 cites W2002211489 @default.
• W2158049152 cites W2005539486 @default.
• W2158049152 cites W2006044521 @default.
• W2158049152 cites W2012124023 @default.
• W2158049152 cites W2014144028 @default.
• W2158049152 cites W2025073888 @default.
• W2158049152 cites W2025134001 @default.
• W2158049152 cites W2030938630 @default.
• W2158049152 cites W2047836890 @default.
• W2158049152 cites W2061365466 @default.
• W2158049152 cites W2081095555 @default.
• W2158049152 cites W2081444493 @default.
• W2158049152 cites W2088759134 @default.
• W2158049152 cites W2090842782 @default.
• W2158049152 cites W2092914889 @default.
• W2158049152 cites W2110330165 @default.
• W2158049152 cites W2117344826 @default.
• W2158049152 cites W2126788226 @default.
• W2158049152 cites W2137445925 @default.
• W2158049152 cites W2143004446 @default.
• W2158049152 cites W2151589110 @default.
• W2158049152 cites W2153719270 @default.
• W2158049152 cites W2527980135 @default.
• W2158049152 doi "https://doi.org/10.1152/ajpheart.00660.2013" @default.
• W2158049152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3949051" @default.
• W2158049152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24441547" @default.
• W2158049152 hasPublicationYear "2014" @default.
• W2158049152 type Work @default.
• W2158049152 sameAs 2158049152 @default.
• W2158049152 citedByCount "49" @default.
• W2158049152 countsByYear W21580491522014 @default.
• W2158049152 countsByYear W21580491522015 @default.
• W2158049152 countsByYear W21580491522016 @default.
• W2158049152 countsByYear W21580491522017 @default.
• W2158049152 countsByYear W21580491522018 @default.
• W2158049152 countsByYear W21580491522019 @default.
• W2158049152 countsByYear W21580491522020 @default.
• W2158049152 countsByYear W21580491522021 @default.
• W2158049152 countsByYear W21580491522022 @default.
• W2158049152 crossrefType "journal-article" @default.
• W2158049152 hasAuthorship W2158049152A5038709923 @default.
• W2158049152 hasAuthorship W2158049152A5064257229 @default.
• W2158049152 hasAuthorship W2158049152A5072585999 @default.
• W2158049152 hasAuthorship W2158049152A5074883482 @default.
• W2158049152 hasAuthorship W2158049152A5077806459 @default.
• W2158049152 hasAuthorship W2158049152A5089124744 @default.
• W2158049152 hasBestOaLocation W21580491522 @default.
• W2158049152 hasConcept C126322002 @default.
• W2158049152 hasConcept C178790620 @default.
• W2158049152 hasConcept C181199279 @default.
• W2158049152 hasConcept C184235292 @default.
• W2158049152 hasConcept C185592680 @default.
• W2158049152 hasConcept C188027245 @default.
• W2158049152 hasConcept C2777468819 @default.
• W2158049152 hasConcept C2777553025 @default.
• W2158049152 hasConcept C2779201268 @default.
• W2158049152 hasConcept C2779676291 @default.
• W2158049152 hasConcept C2780105360 @default.
• W2158049152 hasConcept C515207424 @default.
• W2158049152 hasConcept C519581460 @default.
• W2158049152 hasConcept C541997718 @default.
• W2158049152 hasConcept C55493867 @default.
• W2158049152 hasConcept C71924100 @default.
• W2158049152 hasConcept C98274493 @default.
• W2158049152 hasConceptScore W2158049152C126322002 @default.
• W2158049152 hasConceptScore W2158049152C178790620 @default.
• W2158049152 hasConceptScore W2158049152C181199279 @default.
• W2158049152 hasConceptScore W2158049152C184235292 @default.
• W2158049152 hasConceptScore W2158049152C185592680 @default.
• W2158049152 hasConceptScore W2158049152C188027245 @default.
• W2158049152 hasConceptScore W2158049152C2777468819 @default.
• W2158049152 hasConceptScore W2158049152C2777553025 @default.
• W2158049152 hasConceptScore W2158049152C2779201268 @default.
• W2158049152 hasConceptScore W2158049152C2779676291 @default.
• W2158049152 hasConceptScore W2158049152C2780105360 @default.
• W2158049152 hasConceptScore W2158049152C515207424 @default.
• W2158049152 hasConceptScore W2158049152C519581460 @default.
• W2158049152 hasConceptScore W2158049152C541997718 @default.

• next