FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158049208> ?p ?o ?g. }

• W2158049208 endingPage "255" @default.
• W2158049208 startingPage "240" @default.
• W2158049208 abstract "A detailed understanding of the signaling pathways by which c-Myc elicits apoptosis has proven elusive. In the current study, we have evaluated whether the activation of the mitochondrial apoptotic signaling pathway is linked to c-Myc induction of a subset of genes involved in mitochondrial biogenesis. Cytochrome c and other nuclear-encoded mitochondrial genes are regulated by the transcription factor nuclear respiratory factor-1 (NRF-1). The consensus binding sequence (T/C)GCGCA(C/T)GCGC(A/G) of NRF-1 includes a noncanonical CA(C/T)GCG Myc:MAX binding site. In this study, we establish a link between the induction of NRF-1 target genes and sensitization to apoptosis on serum depletion. We demonstrate, by using Northern analysis, transactivation assays, and in vitro and in vivo promoter binding assays that cytochrome c is a direct target of c-Myc. Like c-Myc, NRF-1 overexpression sensitizes cells to apoptosis on serum depletion. We also demonstrate that selective interference with c-Myc induction of NRF-1 target genes by using a dominant-negative NRF-1 prevented c-Myc-induced apoptosis, without affecting c-Myc-dependent proliferation. These results suggest that c-myc expression leads to mitochondrial dysfunction and apoptosis by deregulating genes involved in mitochondrial function." @default.
• W2158049208 created "2016-06-24" @default.
• W2158049208 creator A5003321923 @default.
• W2158049208 creator A5016626619 @default.
• W2158049208 creator A5064044079 @default.
• W2158049208 date "2003-01-15" @default.
• W2158049208 modified "2023-10-12" @default.
• W2158049208 title "c-MYC apoptotic function is mediated by NRF-1 target genes" @default.
• W2158049208 cites W1488283633 @default.
• W2158049208 cites W1494925286 @default.
• W2158049208 cites W1535244363 @default.
• W2158049208 cites W1547608553 @default.
• W2158049208 cites W1554666790 @default.
• W2158049208 cites W159550858 @default.
• W2158049208 cites W1881081860 @default.
• W2158049208 cites W1902193863 @default.
• W2158049208 cites W1904882776 @default.
• W2158049208 cites W1971082641 @default.
• W2158049208 cites W1974188155 @default.
• W2158049208 cites W1976632546 @default.
• W2158049208 cites W1977795050 @default.
• W2158049208 cites W1979796397 @default.
• W2158049208 cites W1981527987 @default.
• W2158049208 cites W1987779112 @default.
• W2158049208 cites W1991886593 @default.
• W2158049208 cites W1993279449 @default.
• W2158049208 cites W1997208169 @default.
• W2158049208 cites W2002662437 @default.
• W2158049208 cites W2004499394 @default.
• W2158049208 cites W2007021266 @default.
• W2158049208 cites W2008550494 @default.
• W2158049208 cites W2009603041 @default.
• W2158049208 cites W2011548785 @default.
• W2158049208 cites W2012181342 @default.
• W2158049208 cites W2012528207 @default.
• W2158049208 cites W2014993721 @default.
• W2158049208 cites W2018119239 @default.
• W2158049208 cites W2025713422 @default.
• W2158049208 cites W2028680679 @default.
• W2158049208 cites W2037872087 @default.
• W2158049208 cites W2056174109 @default.
• W2158049208 cites W2064772366 @default.
• W2158049208 cites W2067953176 @default.
• W2158049208 cites W2069330945 @default.
• W2158049208 cites W2070579800 @default.
• W2158049208 cites W2073630190 @default.
• W2158049208 cites W2081948388 @default.
• W2158049208 cites W2091664490 @default.
• W2158049208 cites W2097774235 @default.
• W2158049208 cites W2101904615 @default.
• W2158049208 cites W2104014517 @default.
• W2158049208 cites W2105988181 @default.
• W2158049208 cites W2115526120 @default.
• W2158049208 cites W2123206370 @default.
• W2158049208 cites W2128719495 @default.
• W2158049208 cites W2130344015 @default.
• W2158049208 cites W2130866079 @default.
• W2158049208 cites W2132625535 @default.
• W2158049208 cites W2134979684 @default.
• W2158049208 cites W2144691110 @default.
• W2158049208 cites W2145115717 @default.
• W2158049208 cites W2149357952 @default.
• W2158049208 cites W2159972538 @default.
• W2158049208 cites W2173353469 @default.
• W2158049208 cites W2176573833 @default.
• W2158049208 cites W2181534894 @default.
• W2158049208 cites W2320279754 @default.
• W2158049208 cites W2320732213 @default.
• W2158049208 cites W2327054845 @default.
• W2158049208 cites W2333480261 @default.
• W2158049208 cites W2352138887 @default.
• W2158049208 cites W4237567990 @default.
• W2158049208 doi "https://doi.org/10.1101/gad.1032503" @default.
• W2158049208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/195978" @default.
• W2158049208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12533512" @default.
• W2158049208 hasPublicationYear "2003" @default.
• W2158049208 type Work @default.
• W2158049208 sameAs 2158049208 @default.
• W2158049208 citedByCount "110" @default.
• W2158049208 countsByYear W21580492082012 @default.
• W2158049208 countsByYear W21580492082013 @default.
• W2158049208 countsByYear W21580492082014 @default.
• W2158049208 countsByYear W21580492082015 @default.
• W2158049208 countsByYear W21580492082016 @default.
• W2158049208 countsByYear W21580492082017 @default.
• W2158049208 countsByYear W21580492082018 @default.
• W2158049208 countsByYear W21580492082019 @default.
• W2158049208 countsByYear W21580492082020 @default.
• W2158049208 countsByYear W21580492082021 @default.
• W2158049208 countsByYear W21580492082022 @default.
• W2158049208 countsByYear W21580492082023 @default.
• W2158049208 crossrefType "journal-article" @default.
• W2158049208 hasAuthorship W2158049208A5003321923 @default.
• W2158049208 hasAuthorship W2158049208A5016626619 @default.
• W2158049208 hasAuthorship W2158049208A5064044079 @default.
• W2158049208 hasBestOaLocation W21580492081 @default.
• W2158049208 hasConcept C104317684 @default.
• W2158049208 hasConcept C1292079 @default.

• next