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• W2158056146 abstract "Background Defects caused by ethanol ( E t OH ) exposure during development can be different depending on the time of observation. To investigate this temporal component of developmental delay, we use the fast‐developing nematode model C aenorhabditis elegans . We first defined the longitudinal effects of E t OH on development using age‐appropriate markers and then closely followed embryonic development before, during, and after E t OH exposure. Methods C . elegans embryos were bathed in 0 to 20% E t OH (w/w in ddH 2 O ) for 8 hours or were left untreated during embryonic development. Development was followed longitudinally and scored as embryonic stage at the end of the exposure, hatch time, hatching probability (mortality), body length, postembryonic stage, and egg‐laying pattern. The rate of in vivo embryonic development was observed hourly for 24 hours covering times before, during, and after E t OH exposure. Results After exposure to 10% E t OH , embryos were at younger embryonic stages, hatched later, and had higher mortality compared to unexposed controls. Embryos exposed to 5% E t OH were at normal embryonic stages, showed no change in mortality, but hatched later than controls. Both E t OH groups showed shorter mean body lengths and slower postembryonic development; however, the 5% group recovered to control levels faster than the 10% group. The pattern of egg laying was delayed in the 10% group, but not in the 5% group. Hourly in vivo observations revealed that a developmental delay was first visible a few hours into 10% E t OH exposure and that the delay increased after the removal of E t OH exposure. Conclusions Developmental delays occurred during and immediately after exposure and were not uniform but rather dynamic. This article highlights the importance of investigating E t OH ‐induced defects using different markers and at multiple time points. Attention to temporal effects during and immediately after E t OH exposure can provide understanding of these sensitive time points for observation and treatment." @default.
• W2158056146 created "2016-06-24" @default.
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• W2158056146 date "2012-06-22" @default.
• W2158056146 modified "2023-10-16" @default.
• W2158056146 title "Dynamic and Persistent Effects of Ethanol Exposure on Development: An In Vivo Analysis During and After Embryonic Ethanol Exposure in<i>Caenorhabditis elegans</i>" @default.
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• W2158056146 doi "https://doi.org/10.1111/j.1530-0277.2012.01856.x" @default.
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