Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158058952> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2158058952 abstract "The effect of dexamethasone (DEX) and its interaction with morphine has been studied on transmurally-stimulated guinea-pig ileum preparation, gastrointestinal transit and analgesia. TRANSMURALLY-STIMULATED GUINEA-PIG ILEUM PREPARATION: DEX dose-dependently reduced the contractions of the ileum. Proteic synthesis inhibitors did not modify the inhibition induced by DEX whereas RU-38486, a glucocorticoid antagonist receptor, antagonized completely the inhibitory effect of DEX. GASTROINTESTINAL TRANSIT: DEX was found to antagonize morphine-, atropine- and verapamil-induced constipation. Cycloheximide does not modify the DEX effects. RU-38486 reverses both the inhibitory action of DEX on gastrointestinal transit and its reducing effect on morphine-induced constipation.DEX reduced the antinociception induced by mu agonists, morphine, DAMGO and beta endorphin whereas the steroid exerted little or no influence on the antinociception induced by a delta1 agonist, DPDPE and delta2 agonist deltorphin II. DEX potentiated the antinociception induced by the K agonist, U50,488. Cycloheximide, a protein synthesis inhibitor, prevented the antagonism by DEX of responses to the mu opioid agonists. Finally, i.c.v. injection of DEX significantly reduced morphine analgesia in Swiss mice whereas no effects were observed in DBA/2J and C57BL/6 mice. In addition, i.p. injection of DEX significantly reduced morphine analgesia in all three strains. Our data indicate that in the rodent brain there is an important functional interaction between the corticosteroid and the opioid systems at least at the mu. receptor level, while delta and K receptors are modulated in different ways. These results, particularly the effects of drug interaction for i.c.v. administration, strongly confirm a central site for DEX and RU 38486 action as well as the use of different genetic strains may provide a useful approach for studying DEX-morphine analgesia interaction." @default.
- W2158058952 created "2016-06-24" @default.
- W2158058952 creator A5009090023 @default.
- W2158058952 creator A5084784161 @default.
- W2158058952 date "2008-06-01" @default.
- W2158058952 modified "2023-09-26" @default.
- W2158058952 title "Functional Interference of Dexamethasone on Some Morphine Effects:Hypothesis for the Steroid-Opioid Interaction" @default.
- W2158058952 doi "https://doi.org/10.2174/157488908784534612" @default.
- W2158058952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18537773" @default.
- W2158058952 hasPublicationYear "2008" @default.
- W2158058952 type Work @default.
- W2158058952 sameAs 2158058952 @default.
- W2158058952 citedByCount "8" @default.
- W2158058952 countsByYear W21580589522015 @default.
- W2158058952 countsByYear W21580589522018 @default.
- W2158058952 crossrefType "journal-article" @default.
- W2158058952 hasAuthorship W2158058952A5009090023 @default.
- W2158058952 hasAuthorship W2158058952A5084784161 @default.
- W2158058952 hasConcept C126322002 @default.
- W2158058952 hasConcept C134018914 @default.
- W2158058952 hasConcept C14397066 @default.
- W2158058952 hasConcept C170493617 @default.
- W2158058952 hasConcept C185592680 @default.
- W2158058952 hasConcept C2777226302 @default.
- W2158058952 hasConcept C2777389121 @default.
- W2158058952 hasConcept C2778750930 @default.
- W2158058952 hasConcept C2778938600 @default.
- W2158058952 hasConcept C2780401358 @default.
- W2158058952 hasConcept C2781063702 @default.
- W2158058952 hasConcept C71924100 @default.
- W2158058952 hasConcept C98274493 @default.
- W2158058952 hasConceptScore W2158058952C126322002 @default.
- W2158058952 hasConceptScore W2158058952C134018914 @default.
- W2158058952 hasConceptScore W2158058952C14397066 @default.
- W2158058952 hasConceptScore W2158058952C170493617 @default.
- W2158058952 hasConceptScore W2158058952C185592680 @default.
- W2158058952 hasConceptScore W2158058952C2777226302 @default.
- W2158058952 hasConceptScore W2158058952C2777389121 @default.
- W2158058952 hasConceptScore W2158058952C2778750930 @default.
- W2158058952 hasConceptScore W2158058952C2778938600 @default.
- W2158058952 hasConceptScore W2158058952C2780401358 @default.
- W2158058952 hasConceptScore W2158058952C2781063702 @default.
- W2158058952 hasConceptScore W2158058952C71924100 @default.
- W2158058952 hasConceptScore W2158058952C98274493 @default.
- W2158058952 hasLocation W21580589521 @default.
- W2158058952 hasLocation W21580589522 @default.
- W2158058952 hasOpenAccess W2158058952 @default.
- W2158058952 hasPrimaryLocation W21580589521 @default.
- W2158058952 hasRelatedWork W1965997313 @default.
- W2158058952 hasRelatedWork W1968298659 @default.
- W2158058952 hasRelatedWork W1986886837 @default.
- W2158058952 hasRelatedWork W1987166791 @default.
- W2158058952 hasRelatedWork W1999426514 @default.
- W2158058952 hasRelatedWork W2009219892 @default.
- W2158058952 hasRelatedWork W2029049602 @default.
- W2158058952 hasRelatedWork W2029327352 @default.
- W2158058952 hasRelatedWork W2033657503 @default.
- W2158058952 hasRelatedWork W2053012898 @default.
- W2158058952 hasRelatedWork W2059143513 @default.
- W2158058952 hasRelatedWork W2062978622 @default.
- W2158058952 hasRelatedWork W2066789566 @default.
- W2158058952 hasRelatedWork W2099734724 @default.
- W2158058952 hasRelatedWork W2245416148 @default.
- W2158058952 hasRelatedWork W2254328535 @default.
- W2158058952 hasRelatedWork W2294558654 @default.
- W2158058952 hasRelatedWork W2403293870 @default.
- W2158058952 hasRelatedWork W3187785263 @default.
- W2158058952 hasRelatedWork W1861741799 @default.
- W2158058952 isParatext "false" @default.
- W2158058952 isRetracted "false" @default.
- W2158058952 magId "2158058952" @default.
- W2158058952 workType "article" @default.