FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158097707> ?p ?o ?g. }

• W2158097707 abstract "Sepsis and consequent multi-organ failure are the leading causes of mortality in critically ill patients. Numerous therapeutic strategies, which yielded promising results in preclinical studies, have failed to show any efficacy in clinical trials. Historically, most of our (patho)physiological understanding of cardiovascular regulation in health and disease has been established in larger mammals, e.g., dog, pig, and sheep. However, a very large body of the literature collected over recent decades originates from investigations in rodents. Despite their small size, which makes surgery difficult and limits repetitive blood sampling, murine models have been widely used, not because they are more faithful to adult human pathophysiology than larger mammals but because they are inexpensive, easy to handle and care for, and with availability of gene knockout and overexpression strains. Investigators have performed studies without necessarily having a good appreciation of some fundamental differences in the physiology of rodents. These have been long established by comparative physiologists, yet have never been taught in any medical school. One can query the logic of inferring information on mechanisms involved in septic shock using species capable of decreasing their high resting metabolic rate both rapidly and massively, and with the associated circulatory and respiratory responses. Mouse models of acute inflammatory disorders have recently been questioned by Seok et al. [1] who found that “genomic responses to different acute inflammatory stresses are highly similar in humans”, whereas “these responses are not reproduced in current mouse models”. In this context, Zolfaghari et al. [2] compared the metabolic responses to polymicrobial sepsis in rats and mice. Their main findings were that mice presented with a progressive drop in whole body O2 uptake and a concurrent fall in body temperature, which was only partially restored by external warming. This marked metabolic depression coincided with pronounced impairment of left heart systolic contractility. In sharp contrast, only severely ill rats showed a comparably decreased cardiac output, and the metabolic depression was only present during the late premortem period. How can we explain these findings by Zolfaghari et al. [2]? The authors have the merit of raising an issue of crucial importance for critical care research, i.e., whether or" @default.
• W2158097707 created "2016-06-24" @default.
• W2158097707 creator A5033389583 @default.
• W2158097707 creator A5077107031 @default.
• W2158097707 date "2013-10-29" @default.
• W2158097707 modified "2023-09-25" @default.
• W2158097707 title "A mouse is not a rat is not a man: species-specific metabolic responses to sepsis - a nail in the coffin of murine models for critical care research?" @default.
• W2158097707 cites W1923702019 @default.
• W2158097707 cites W1971123049 @default.
• W2158097707 cites W1980949096 @default.
• W2158097707 cites W1996021211 @default.
• W2158097707 cites W1999300999 @default.
• W2158097707 cites W2002397505 @default.
• W2158097707 cites W2005681704 @default.
• W2158097707 cites W2007032123 @default.
• W2158097707 cites W2013521475 @default.
• W2158097707 cites W2020173969 @default.
• W2158097707 cites W2028662660 @default.
• W2158097707 cites W2028924346 @default.
• W2158097707 cites W2029334399 @default.
• W2158097707 cites W2036057485 @default.
• W2158097707 cites W2059534198 @default.
• W2158097707 cites W2066381270 @default.
• W2158097707 cites W2073450422 @default.
• W2158097707 cites W2074852058 @default.
• W2158097707 cites W2075469538 @default.
• W2158097707 cites W2077346830 @default.
• W2158097707 cites W2082778932 @default.
• W2158097707 cites W2084940755 @default.
• W2158097707 cites W2090035970 @default.
• W2158097707 cites W2091577537 @default.
• W2158097707 cites W2147907319 @default.
• W2158097707 cites W2152547415 @default.
• W2158097707 cites W2156742121 @default.
• W2158097707 cites W2161771297 @default.
• W2158097707 cites W2163038184 @default.
• W2158097707 cites W2164353721 @default.
• W2158097707 cites W2315827370 @default.
• W2158097707 doi "https://doi.org/10.1186/2197-425x-1-7" @default.
• W2158097707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4796700" @default.
• W2158097707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26266795" @default.
• W2158097707 hasPublicationYear "2013" @default.
• W2158097707 type Work @default.
• W2158097707 sameAs 2158097707 @default.
• W2158097707 citedByCount "32" @default.
• W2158097707 countsByYear W21580977072014 @default.
• W2158097707 countsByYear W21580977072015 @default.
• W2158097707 countsByYear W21580977072016 @default.
• W2158097707 countsByYear W21580977072017 @default.
• W2158097707 countsByYear W21580977072018 @default.
• W2158097707 countsByYear W21580977072019 @default.
• W2158097707 countsByYear W21580977072020 @default.
• W2158097707 countsByYear W21580977072021 @default.
• W2158097707 countsByYear W21580977072022 @default.
• W2158097707 countsByYear W21580977072023 @default.
• W2158097707 crossrefType "journal-article" @default.
• W2158097707 hasAuthorship W2158097707A5033389583 @default.
• W2158097707 hasAuthorship W2158097707A5077107031 @default.
• W2158097707 hasBestOaLocation W21580977071 @default.
• W2158097707 hasConcept C105702510 @default.
• W2158097707 hasConcept C126322002 @default.
• W2158097707 hasConcept C177713679 @default.
• W2158097707 hasConcept C191897082 @default.
• W2158097707 hasConcept C192562407 @default.
• W2158097707 hasConcept C2777852167 @default.
• W2158097707 hasConcept C2778384902 @default.
• W2158097707 hasConcept C2779207954 @default.
• W2158097707 hasConcept C71924100 @default.
• W2158097707 hasConceptScore W2158097707C105702510 @default.
• W2158097707 hasConceptScore W2158097707C126322002 @default.
• W2158097707 hasConceptScore W2158097707C177713679 @default.
• W2158097707 hasConceptScore W2158097707C191897082 @default.
• W2158097707 hasConceptScore W2158097707C192562407 @default.
• W2158097707 hasConceptScore W2158097707C2777852167 @default.
• W2158097707 hasConceptScore W2158097707C2778384902 @default.
• W2158097707 hasConceptScore W2158097707C2779207954 @default.
• W2158097707 hasConceptScore W2158097707C71924100 @default.
• W2158097707 hasIssue "1" @default.
• W2158097707 hasLocation W21580977071 @default.
• W2158097707 hasLocation W21580977072 @default.
• W2158097707 hasLocation W21580977073 @default.
• W2158097707 hasLocation W21580977074 @default.
• W2158097707 hasOpenAccess W2158097707 @default.
• W2158097707 hasPrimaryLocation W21580977071 @default.
• W2158097707 hasRelatedWork W2027500313 @default.
• W2158097707 hasRelatedWork W2408010109 @default.
• W2158097707 hasRelatedWork W2410416858 @default.
• W2158097707 hasRelatedWork W2416029306 @default.
• W2158097707 hasRelatedWork W2417077106 @default.
• W2158097707 hasRelatedWork W2461029315 @default.
• W2158097707 hasRelatedWork W2462757955 @default.
• W2158097707 hasRelatedWork W25356043 @default.
• W2158097707 hasRelatedWork W4313205132 @default.
• W2158097707 hasRelatedWork W2287176708 @default.
• W2158097707 hasVolume "1" @default.
• W2158097707 isParatext "false" @default.
• W2158097707 isRetracted "false" @default.
• W2158097707 magId "2158097707" @default.
• W2158097707 workType "article" @default.