FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158109071> ?p ?o ?g. }

• W2158109071 endingPage "2019" @default.
• W2158109071 startingPage "2015" @default.
• W2158109071 abstract "Abstract Purpose: CYP1B1 activates various environmental carcinogens in human tissues, including renal tissues. We hypothesize that certain polymorphisms of the CYP1B1 gene are risk factors for renal cell cancer. The rationale for this hypothesis is that chemical procarcinogenic compounds require metabolic activation by oxidative enzymes such as CYP1B1 to be transformed into potentially carcinogenic forms. To test this hypothesis, we investigated the genotypic distributions of six different loci on the CYP1B1 gene and their association with renal cell cancer. Experimental Design: DNA from 211 cases of human renal cell cancer and 200 healthy controls was analyzed by sequence-specific PCR and direct DNA sequencing to determine the genotypic frequencies of six different polymorphic loci on the CYP1B1 gene. Results: The results of this study demonstrate that the frequencies of genotype 119T/T and genotype 432G/G were significantly higher in renal cell cancer patients compared with healthy normal controls. The relative risks were calculated as 3.01 and 2.17 for genotypes 119T/T and 432G/G, respectively, in renal cell carcinoma patients. These genotypic distributions were also significantly different between male and female patients. The relative risks of genotype 119T/T were calculated as 3.95 in males and 1.92 in females, and the relative risks of genotype 432G/G were calculated as 2.81 in males and 1.35 in females. Conclusions: The present study demonstrates for the first time that the polymorphisms at codons 119 and 432 may be risk factors for renal cancer, especially in the male population." @default.
• W2158109071 created "2016-06-24" @default.
• W2158109071 creator A5009010132 @default.
• W2158109071 creator A5027705783 @default.
• W2158109071 creator A5038105097 @default.
• W2158109071 creator A5038177621 @default.
• W2158109071 creator A5038826847 @default.
• W2158109071 creator A5040104003 @default.
• W2158109071 creator A5071471877 @default.
• W2158109071 creator A5085150253 @default.
• W2158109071 creator A5091277409 @default.
• W2158109071 date "2004-03-15" @default.
• W2158109071 modified "2023-10-10" @default.
• W2158109071 title "Polymorphisms of the <b> <i>CYP1B1</i> </b> Gene as Risk Factors for Human Renal Cell Cancer" @default.
• W2158109071 cites W1918014554 @default.
• W2158109071 cites W1973113456 @default.
• W2158109071 cites W1975957761 @default.
• W2158109071 cites W2029731237 @default.
• W2158109071 cites W2051918551 @default.
• W2158109071 cites W2065999267 @default.
• W2158109071 cites W2080837912 @default.
• W2158109071 cites W2080986961 @default.
• W2158109071 cites W2132762752 @default.
• W2158109071 cites W2148898638 @default.
• W2158109071 cites W2151017428 @default.
• W2158109071 cites W2151765685 @default.
• W2158109071 cites W2151988692 @default.
• W2158109071 cites W2166260496 @default.
• W2158109071 cites W2768600953 @default.
• W2158109071 cites W4236017930 @default.
• W2158109071 doi "https://doi.org/10.1158/1078-0432.ccr-03-0166" @default.
• W2158109071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15041720" @default.
• W2158109071 hasPublicationYear "2004" @default.
• W2158109071 type Work @default.
• W2158109071 sameAs 2158109071 @default.
• W2158109071 citedByCount "39" @default.
• W2158109071 countsByYear W21581090712012 @default.
• W2158109071 countsByYear W21581090712014 @default.
• W2158109071 countsByYear W21581090712015 @default.
• W2158109071 countsByYear W21581090712020 @default.
• W2158109071 countsByYear W21581090712022 @default.
• W2158109071 crossrefType "journal-article" @default.
• W2158109071 hasAuthorship W2158109071A5009010132 @default.
• W2158109071 hasAuthorship W2158109071A5027705783 @default.
• W2158109071 hasAuthorship W2158109071A5038105097 @default.
• W2158109071 hasAuthorship W2158109071A5038177621 @default.
• W2158109071 hasAuthorship W2158109071A5038826847 @default.
• W2158109071 hasAuthorship W2158109071A5040104003 @default.
• W2158109071 hasAuthorship W2158109071A5071471877 @default.
• W2158109071 hasAuthorship W2158109071A5085150253 @default.
• W2158109071 hasAuthorship W2158109071A5091277409 @default.
• W2158109071 hasBestOaLocation W21581090711 @default.
• W2158109071 hasConcept C104317684 @default.
• W2158109071 hasConcept C114246631 @default.
• W2158109071 hasConcept C121608353 @default.
• W2158109071 hasConcept C126322002 @default.
• W2158109071 hasConcept C134018914 @default.
• W2158109071 hasConcept C135763542 @default.
• W2158109071 hasConcept C143998085 @default.
• W2158109071 hasConcept C155701950 @default.
• W2158109071 hasConcept C2777472916 @default.
• W2158109071 hasConcept C2781068499 @default.
• W2158109071 hasConcept C2908647359 @default.
• W2158109071 hasConcept C502942594 @default.
• W2158109071 hasConcept C526171541 @default.
• W2158109071 hasConcept C54355233 @default.
• W2158109071 hasConcept C62231903 @default.
• W2158109071 hasConcept C71924100 @default.
• W2158109071 hasConcept C86803240 @default.
• W2158109071 hasConcept C99454951 @default.
• W2158109071 hasConceptScore W2158109071C104317684 @default.
• W2158109071 hasConceptScore W2158109071C114246631 @default.
• W2158109071 hasConceptScore W2158109071C121608353 @default.
• W2158109071 hasConceptScore W2158109071C126322002 @default.
• W2158109071 hasConceptScore W2158109071C134018914 @default.
• W2158109071 hasConceptScore W2158109071C135763542 @default.
• W2158109071 hasConceptScore W2158109071C143998085 @default.
• W2158109071 hasConceptScore W2158109071C155701950 @default.
• W2158109071 hasConceptScore W2158109071C2777472916 @default.
• W2158109071 hasConceptScore W2158109071C2781068499 @default.
• W2158109071 hasConceptScore W2158109071C2908647359 @default.
• W2158109071 hasConceptScore W2158109071C502942594 @default.
• W2158109071 hasConceptScore W2158109071C526171541 @default.
• W2158109071 hasConceptScore W2158109071C54355233 @default.
• W2158109071 hasConceptScore W2158109071C62231903 @default.
• W2158109071 hasConceptScore W2158109071C71924100 @default.
• W2158109071 hasConceptScore W2158109071C86803240 @default.
• W2158109071 hasConceptScore W2158109071C99454951 @default.
• W2158109071 hasIssue "6" @default.
• W2158109071 hasLocation W21581090711 @default.
• W2158109071 hasLocation W21581090712 @default.
• W2158109071 hasOpenAccess W2158109071 @default.
• W2158109071 hasPrimaryLocation W21581090711 @default.
• W2158109071 hasRelatedWork W1963497287 @default.
• W2158109071 hasRelatedWork W1966469946 @default.
• W2158109071 hasRelatedWork W2001388371 @default.
• W2158109071 hasRelatedWork W2053501298 @default.
• W2158109071 hasRelatedWork W2081158024 @default.

• next