Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158115890> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2158115890 endingPage "948" @default.
- W2158115890 startingPage "943" @default.
- W2158115890 abstract "Guidelines identify a 3-month topical application of an ultra-potent corticosteroid ointment as the mainstay of medical treatment for vulvar lichen sclerosus (VLS). However, there are no trials providing evidence that any specific corticosteroid is superior to another.To assess the effectiveness and safety of a 12-week application of mometasone furoate (MMF) 0.1% ointment, with a tapering regimen, in achieving control of VLS signs and symptoms and to detect potential risk factors for VLS non-response.147 patients affected with VLS were enrolled in a 12-week active treatment phase (ATP) with topical 0.1% MMF. The primary efficacy endpoint was the rate of patients achieving clinical response, as defined by protocol parameters. The secondary efficacy endpoint was to assess the changes of mean VLS-related symptoms after the 12-week ATP compared with baseline.By the end of the ATP, 113 patients (80.7%) experienced a treatment response, whereas 27 women (19.3%) were judged as non-responders. Mean symptom scores decreased significantly in the study patients, regardless of their clinical response at the end of the ATP. Among all the epidemiological and clinical data considered, only the absence of previous medical therapies was found to be related to a significantly higher risk of non-response to treatment.Application of 0.1% MMF ointment for 12 weeks on a tapering regimen was found to be an effective and safe therapy option in the ATP of VLS and could represent an alternative first-line treatment to an ultra-potent molecule." @default.
- W2158115890 created "2016-06-24" @default.
- W2158115890 creator A5027797711 @default.
- W2158115890 creator A5048861972 @default.
- W2158115890 creator A5055259474 @default.
- W2158115890 creator A5067756888 @default.
- W2158115890 date "2013-07-23" @default.
- W2158115890 modified "2023-10-16" @default.
- W2158115890 title "Mometasone fuoroate 0.1% ointment in the treatment of vulvar lichen sclerosus: a study of efficacy and safety on a large cohort of patients" @default.
- W2158115890 cites W1914759045 @default.
- W2158115890 cites W1973723090 @default.
- W2158115890 cites W1975614869 @default.
- W2158115890 cites W1976832091 @default.
- W2158115890 cites W1987172723 @default.
- W2158115890 cites W1990597457 @default.
- W2158115890 cites W1991288499 @default.
- W2158115890 cites W2002463594 @default.
- W2158115890 cites W2002569779 @default.
- W2158115890 cites W2065017552 @default.
- W2158115890 cites W2077851041 @default.
- W2158115890 cites W2088047575 @default.
- W2158115890 cites W2154082835 @default.
- W2158115890 cites W2160929341 @default.
- W2158115890 cites W2165456905 @default.
- W2158115890 cites W4211081989 @default.
- W2158115890 cites W4233956541 @default.
- W2158115890 cites W4241756135 @default.
- W2158115890 doi "https://doi.org/10.1111/jdv.12219" @default.
- W2158115890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23879234" @default.
- W2158115890 hasPublicationYear "2013" @default.
- W2158115890 type Work @default.
- W2158115890 sameAs 2158115890 @default.
- W2158115890 citedByCount "17" @default.
- W2158115890 countsByYear W21581158902014 @default.
- W2158115890 countsByYear W21581158902015 @default.
- W2158115890 countsByYear W21581158902016 @default.
- W2158115890 countsByYear W21581158902017 @default.
- W2158115890 countsByYear W21581158902018 @default.
- W2158115890 countsByYear W21581158902019 @default.
- W2158115890 countsByYear W21581158902020 @default.
- W2158115890 countsByYear W21581158902021 @default.
- W2158115890 crossrefType "journal-article" @default.
- W2158115890 hasAuthorship W2158115890A5027797711 @default.
- W2158115890 hasAuthorship W2158115890A5048861972 @default.
- W2158115890 hasAuthorship W2158115890A5055259474 @default.
- W2158115890 hasAuthorship W2158115890A5067756888 @default.
- W2158115890 hasConcept C126322002 @default.
- W2158115890 hasConcept C16005928 @default.
- W2158115890 hasConcept C203092338 @default.
- W2158115890 hasConcept C2776552008 @default.
- W2158115890 hasConcept C2776804153 @default.
- W2158115890 hasConcept C2781348165 @default.
- W2158115890 hasConcept C2781413609 @default.
- W2158115890 hasConcept C535046627 @default.
- W2158115890 hasConcept C71924100 @default.
- W2158115890 hasConcept C72563966 @default.
- W2158115890 hasConceptScore W2158115890C126322002 @default.
- W2158115890 hasConceptScore W2158115890C16005928 @default.
- W2158115890 hasConceptScore W2158115890C203092338 @default.
- W2158115890 hasConceptScore W2158115890C2776552008 @default.
- W2158115890 hasConceptScore W2158115890C2776804153 @default.
- W2158115890 hasConceptScore W2158115890C2781348165 @default.
- W2158115890 hasConceptScore W2158115890C2781413609 @default.
- W2158115890 hasConceptScore W2158115890C535046627 @default.
- W2158115890 hasConceptScore W2158115890C71924100 @default.
- W2158115890 hasConceptScore W2158115890C72563966 @default.
- W2158115890 hasIssue "7" @default.
- W2158115890 hasLocation W21581158901 @default.
- W2158115890 hasLocation W21581158902 @default.
- W2158115890 hasOpenAccess W2158115890 @default.
- W2158115890 hasPrimaryLocation W21581158901 @default.
- W2158115890 hasRelatedWork W1831952958 @default.
- W2158115890 hasRelatedWork W1999267143 @default.
- W2158115890 hasRelatedWork W2049142096 @default.
- W2158115890 hasRelatedWork W2058848861 @default.
- W2158115890 hasRelatedWork W2081582017 @default.
- W2158115890 hasRelatedWork W2182971224 @default.
- W2158115890 hasRelatedWork W2603773853 @default.
- W2158115890 hasRelatedWork W2783931507 @default.
- W2158115890 hasRelatedWork W4211081403 @default.
- W2158115890 hasRelatedWork W4243793997 @default.
- W2158115890 hasVolume "28" @default.
- W2158115890 isParatext "false" @default.
- W2158115890 isRetracted "false" @default.
- W2158115890 magId "2158115890" @default.
- W2158115890 workType "article" @default.