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• W2158129191 abstract "To evaluate the fibrinolytic activity in a closed surgical wound, in postoperatively drained blood, and during autologous transfusion.Prospective study.National hospital, Norway.9 patients operated on for thoracic scoliosis.Concentrations of plasmin/antiplasmin (PAP), alpha2-antiplasmin, and D-dimers in drained, arterial, and mixed venous blood before, during, and after infusion of 10 ml/kg body weight of postoperatively drained, untreated blood.In drained blood the concentration of alpha2-antiplasmin was 31% of the preoperative arterial control value. Together with the increased concentrations of PAP to 18076 microg/L and D-dimers to 126 mg/L, this indicates extensive fibrinolytic activity in the closed wound. The postoperative autologous transfusion of drained, untreated blood increased the concentration of PAP from 507 to 2453 microg/L and of D-dimer from 0.7 mg/L to 15.3 mg/L in systemic blood.The systemic concentration of fibrin(ogen) degradation products, indicated by D-dimers, after recirculation of drained, untreated blood might impair coagulation. The extensive activation of plasmin might exhaust available alpha2-antiplasmin in the wound and result in postoperative rebleeding." @default.
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• W2158129191 date "2001-03-01" @default.
• W2158129191 modified "2023-10-13" @default.
• W2158129191 title "Fibrinolytic Activity and Postoperative Salvaged Untreated Blood for Autologous Transfusion in Major Orthopaedic Surgery" @default.
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• W2158129191 doi "https://doi.org/10.1080/110241501750099276" @default.
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