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• W2158132553 startingPage "69" @default.
• W2158132553 abstract "Human chorionic gonadotrophin (hCG) is measured in serum and urine for the early detection of ectopic pregnancy, patients with higher risk of miscarriage, embryos or fetuses with chromosome abnormalities, prediction of pre-eclampsia or fetal growth restriction and identification or follow-up of trophoblast neoplasia. This review examines basic knowledge on the heterogeneity of hCG protein core and sugar branches and its relevance to assays used in a clinical setting.The databases Scielo and Medline/Pubmed were consulted for identification of the most relevant published papers. Search terms were gonadotrophin, glycoprotein structure, hCG structure and molecular forms of hCG.The synthesis of alpha (hCGalpha) and beta (hCGbeta) peptide chains and their further glycosylation involve the complex action of different enzymes. After assembly, hCG reaches the cell surface and is secreted as a bioactive heterodimer. The complex cascade of enzymes acting in hCG secretion results in heterogeneous molecular forms. The hCG molecules are differently metabolized by the liver, ovary and kidney, but the majority of hCG forms are excreted in the urine. Intact hCG, hCGalpha, hCGbeta, hyperglycosylated (hCGh), nicked (hCGn) and core fragment of hCGbeta (hCGbetacf) forms have relevant clinical use. The immunogenicity of each hCG variant, their epitopes distribution and the available antibodies are important for the development of specific assays. Depending on the prevalent form or proportion in relation to the intact hCG, the choice of assay for measurement of a specific molecule in a particular clinical setting is paramount.Measurement of hCG and/or its related molecules is useful in clinical practice, but greater awareness is needed worldwide regarding the use of new sensitive and specific assays tailored for different clinical applications." @default.
• W2158132553 created "2016-06-24" @default.
• W2158132553 creator A5001554188 @default.
• W2158132553 creator A5047480968 @default.
• W2158132553 date "2008-10-22" @default.
• W2158132553 modified "2023-09-30" @default.
• W2158132553 title "Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights" @default.
• W2158132553 cites W1483729260 @default.
• W2158132553 cites W1508646570 @default.
• W2158132553 cites W1509442918 @default.
• W2158132553 cites W1510604115 @default.
• W2158132553 cites W1514209292 @default.
• W2158132553 cites W1520703264 @default.
• W2158132553 cites W1551826730 @default.
• W2158132553 cites W1552234264 @default.
• W2158132553 cites W157283203 @default.
• W2158132553 cites W1573223480 @default.
• W2158132553 cites W1578898144 @default.
• W2158132553 cites W1582528266 @default.
• W2158132553 cites W1590243601 @default.
• W2158132553 cites W1598293970 @default.
• W2158132553 cites W1601557881 @default.
• W2158132553 cites W1679692751 @default.
• W2158132553 cites W1902154491 @default.
• W2158132553 cites W191249933 @default.
• W2158132553 cites W19487817 @default.
• W2158132553 cites W1964007074 @default.
• W2158132553 cites W1964034878 @default.
• W2158132553 cites W1964385450 @default.
• W2158132553 cites W1964657659 @default.
• W2158132553 cites W1965773879 @default.
• W2158132553 cites W1965988916 @default.
• W2158132553 cites W1966073943 @default.
• W2158132553 cites W1966794573 @default.
• W2158132553 cites W1967496485 @default.
• W2158132553 cites W1969918461 @default.
• W2158132553 cites W1970884895 @default.
• W2158132553 cites W1972925232 @default.
• W2158132553 cites W1973064760 @default.
• W2158132553 cites W1973847693 @default.
• W2158132553 cites W1974506859 @default.
• W2158132553 cites W1976535744 @default.
• W2158132553 cites W1976771232 @default.
• W2158132553 cites W1977315443 @default.
• W2158132553 cites W1977480963 @default.
• W2158132553 cites W1977616134 @default.
• W2158132553 cites W1978335116 @default.
• W2158132553 cites W1978380229 @default.
• W2158132553 cites W1980033994 @default.
• W2158132553 cites W1981403266 @default.
• W2158132553 cites W1981786622 @default.
• W2158132553 cites W1981861969 @default.
• W2158132553 cites W1983242554 @default.
• W2158132553 cites W1983595431 @default.
• W2158132553 cites W1984518928 @default.
• W2158132553 cites W1986809449 @default.
• W2158132553 cites W1988452587 @default.
• W2158132553 cites W1991318540 @default.
• W2158132553 cites W1992371408 @default.
• W2158132553 cites W1992759808 @default.
• W2158132553 cites W1992773199 @default.
• W2158132553 cites W1992872235 @default.
• W2158132553 cites W1992975585 @default.
• W2158132553 cites W1993710744 @default.
• W2158132553 cites W1993766425 @default.
• W2158132553 cites W1996076003 @default.
• W2158132553 cites W1996929964 @default.
• W2158132553 cites W1997409955 @default.
• W2158132553 cites W1999773758 @default.
• W2158132553 cites W1999799626 @default.
• W2158132553 cites W2001749752 @default.
• W2158132553 cites W2003058718 @default.
• W2158132553 cites W2003100123 @default.
• W2158132553 cites W2004660440 @default.
• W2158132553 cites W2005374717 @default.
• W2158132553 cites W2008345083 @default.
• W2158132553 cites W2012416051 @default.
• W2158132553 cites W2012888087 @default.
• W2158132553 cites W2013173247 @default.
• W2158132553 cites W2013802430 @default.
• W2158132553 cites W2017025161 @default.
• W2158132553 cites W2018681870 @default.
• W2158132553 cites W2019501993 @default.
• W2158132553 cites W2019883796 @default.
• W2158132553 cites W2020367875 @default.
• W2158132553 cites W2020946333 @default.
• W2158132553 cites W2021841381 @default.
• W2158132553 cites W2022351303 @default.
• W2158132553 cites W2022661535 @default.
• W2158132553 cites W2023588351 @default.
• W2158132553 cites W2024131498 @default.
• W2158132553 cites W2024413640 @default.
• W2158132553 cites W2024459158 @default.
• W2158132553 cites W2024707029 @default.
• W2158132553 cites W2027265047 @default.
• W2158132553 cites W2028612664 @default.
• W2158132553 cites W2030122667 @default.
• W2158132553 cites W2031572346 @default.

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