FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158134420> ?p ?o ?g. }

• W2158134420 endingPage "72" @default.
• W2158134420 startingPage "66" @default.
• W2158134420 abstract "Large-scale genomic efforts to study human cancer, such as the cancer gene atlas (TCGA), have identified numerous cancer drivers in a wide variety of tumor types. However, there are limitations to this approach, the mutations and expression or copy number changes that are identified are not always clearly functionally relevant, and only annotated genes and genetic elements are thoroughly queried. The use of complimentary, nonbiased, functional approaches to identify drivers of cancer development and progression is ideal to maximize the rate at which cancer discoveries are achieved. One such approach that has been successful is the use of the Sleeping Beauty (SB) transposon-based mutagenesis system in mice. This system uses a conditionally expressed transposase and mutagenic transposon allele to target mutagenesis to somatic cells of a given tissue in mice to cause random mutations leading to tumor development. Analysis of tumors for transposon common insertion sites (CIS) identifies candidate cancer genes specific to that tumor type. While similar screens have been performed in mice with the PiggyBac (PB) transposon and viral approaches, we limit extensive discussion to SB. Here we discuss the basic structure of these screens, screens that have been performed, methods used to identify CIS." @default.
• W2158134420 created "2016-06-24" @default.
• W2158134420 creator A5005626540 @default.
• W2158134420 creator A5022057184 @default.
• W2158134420 date "2015-02-01" @default.
• W2158134420 modified "2023-09-27" @default.
• W2158134420 title "Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery" @default.
• W2158134420 cites W1531260529 @default.
• W2158134420 cites W1699214082 @default.
• W2158134420 cites W1879626818 @default.
• W2158134420 cites W1888266266 @default.
• W2158134420 cites W1974798136 @default.
• W2158134420 cites W1975880129 @default.
• W2158134420 cites W1977592304 @default.
• W2158134420 cites W1985642836 @default.
• W2158134420 cites W1987704199 @default.
• W2158134420 cites W1992386924 @default.
• W2158134420 cites W1993881548 @default.
• W2158134420 cites W1996393514 @default.
• W2158134420 cites W2008118613 @default.
• W2158134420 cites W2019231810 @default.
• W2158134420 cites W2021231659 @default.
• W2158134420 cites W2026385419 @default.
• W2158134420 cites W2030459426 @default.
• W2158134420 cites W2033141278 @default.
• W2158134420 cites W2033175028 @default.
• W2158134420 cites W2041366584 @default.
• W2158134420 cites W2046695552 @default.
• W2158134420 cites W2047191657 @default.
• W2158134420 cites W2056156818 @default.
• W2158134420 cites W2059794606 @default.
• W2158134420 cites W2065833903 @default.
• W2158134420 cites W2074317576 @default.
• W2158134420 cites W2080399055 @default.
• W2158134420 cites W2083457841 @default.
• W2158134420 cites W2091208239 @default.
• W2158134420 cites W2095477656 @default.
• W2158134420 cites W2105801710 @default.
• W2158134420 cites W2116182014 @default.
• W2158134420 cites W2122293735 @default.
• W2158134420 cites W2122785666 @default.
• W2158134420 cites W2123646732 @default.
• W2158134420 cites W2129042241 @default.
• W2158134420 cites W2130483204 @default.
• W2158134420 cites W2130550193 @default.
• W2158134420 cites W2139869073 @default.
• W2158134420 cites W2142932563 @default.
• W2158134420 cites W2155330630 @default.
• W2158134420 cites W2158374945 @default.
• W2158134420 cites W2164618384 @default.
• W2158134420 cites W2166447146 @default.
• W2158134420 cites W2167404368 @default.
• W2158134420 cites W2169365861 @default.
• W2158134420 cites W2169895148 @default.
• W2158134420 doi "https://doi.org/10.1016/j.gde.2015.04.007" @default.
• W2158134420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4900178" @default.
• W2158134420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26051241" @default.
• W2158134420 hasPublicationYear "2015" @default.
• W2158134420 type Work @default.
• W2158134420 sameAs 2158134420 @default.
• W2158134420 citedByCount "33" @default.
• W2158134420 countsByYear W21581344202015 @default.
• W2158134420 countsByYear W21581344202016 @default.
• W2158134420 countsByYear W21581344202017 @default.
• W2158134420 countsByYear W21581344202018 @default.
• W2158134420 countsByYear W21581344202019 @default.
• W2158134420 countsByYear W21581344202020 @default.
• W2158134420 countsByYear W21581344202021 @default.
• W2158134420 countsByYear W21581344202022 @default.
• W2158134420 countsByYear W21581344202023 @default.
• W2158134420 crossrefType "journal-article" @default.
• W2158134420 hasAuthorship W2158134420A5005626540 @default.
• W2158134420 hasAuthorship W2158134420A5022057184 @default.
• W2158134420 hasBestOaLocation W21581344202 @default.
• W2158134420 hasConcept C104317684 @default.
• W2158134420 hasConcept C107635520 @default.
• W2158134420 hasConcept C121608353 @default.
• W2158134420 hasConcept C127716648 @default.
• W2158134420 hasConcept C133288520 @default.
• W2158134420 hasConcept C141231307 @default.
• W2158134420 hasConcept C16318435 @default.
• W2158134420 hasConcept C172510086 @default.
• W2158134420 hasConcept C207177822 @default.
• W2158134420 hasConcept C28693550 @default.
• W2158134420 hasConcept C4918238 @default.
• W2158134420 hasConcept C501734568 @default.
• W2158134420 hasConcept C54355233 @default.
• W2158134420 hasConcept C70721500 @default.
• W2158134420 hasConcept C86803240 @default.
• W2158134420 hasConceptScore W2158134420C104317684 @default.
• W2158134420 hasConceptScore W2158134420C107635520 @default.
• W2158134420 hasConceptScore W2158134420C121608353 @default.
• W2158134420 hasConceptScore W2158134420C127716648 @default.
• W2158134420 hasConceptScore W2158134420C133288520 @default.
• W2158134420 hasConceptScore W2158134420C141231307 @default.
• W2158134420 hasConceptScore W2158134420C16318435 @default.
• W2158134420 hasConceptScore W2158134420C172510086 @default.
• W2158134420 hasConceptScore W2158134420C207177822 @default.

• next