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- W2158140180 abstract "Dissection of human centromeres is difficult because of the lack of landmarks within highly repeated DNA. We have systematically manipulated a single human X centromere generating a large series of deletion derivatives, which have been examined at four levels: linear DNA structure; the distribution of constitutive centromere proteins; topoisomerase IIalpha cleavage activity; and mitotic stability. We have determined that the human X major alpha-satellite locus, DXZ1, is asymmetrically organized with an active subdomain anchored approximately 150 kb in from the Xp-edge. We demonstrate a major site of topoisomerase II cleavage within this domain that can shift if juxtaposed with a telomere, suggesting that this enzyme recognizes an epigenetic determinant within the DXZ1 chromatin. The observation that the only part of the DXZ1 locus shared by all deletion derivatives is a highly restricted region of <50 kb, which coincides with the topo isomerase II cleavage site, together with the high levels of cleavage detected, identify topoisomerase II as a major player in centromere biology." @default.
- W2158140180 created "2016-06-24" @default.
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- W2158140180 date "2002-10-01" @default.
- W2158140180 modified "2023-10-18" @default.
- W2158140180 title "Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X α-satellite array" @default.
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- W2158140180 doi "https://doi.org/10.1093/emboj/cdf511" @default.
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