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- W2158146543 abstract "Catalysis by the serine proteinases proceeds via a tetrahedral intermediate whose oxyanion is stabilized by hydrogen-bonding in the oxyanion hole. There have been extensive 13C-NMR studies of oxyanion and tetrahedral intermediate stabilization in trypsin, subtilisin and chymotrypsin using substrate-derived chloromethane inhibitors. One of the limitations of these inhibitors is that they irreversibly alkylate the active-site histidine residue which results in the oxyanion not being in the optimal position in the oxyanion hole. Substrate-derived glyoxal inhibitors are reversible inhibitors which, if they form tetrahedral adducts in the same way as substrates form tetrahedral intermediates, will overcome this limitation. Therefore we have synthesized 13C-enriched substrate-derived glyoxal inhibitors which have allowed us to use 13C-NMR and 1H-NMR to determine how they interact with proteinases. It is hoped that these studies will help in the design of specific and highly potent warheads for serine proteinase inhibitors." @default.
- W2158146543 created "2016-06-24" @default.
- W2158146543 creator A5070620012 @default.
- W2158146543 date "2007-05-22" @default.
- W2158146543 modified "2023-10-16" @default.
- W2158146543 title "13C- and 1H-NMR studies of oxyanion and tetrahedral intermediate stabilization by the serine proteinases: optimizing inhibitor warhead specificity and potency by studying the inhibition of the serine proteinases by peptide-derived chloromethane and glyoxal inhibitors" @default.
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- W2158146543 doi "https://doi.org/10.1042/bst0350566" @default.
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