FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158154670> ?p ?o ?g. }

• W2158154670 endingPage "2513" @default.
• W2158154670 startingPage "2507" @default.
• W2158154670 abstract "Purpose To determine the prognostic impact of persistent cytogenetic abnormalities at complete remission (CR) on relapse-free survival (RFS) and overall survival (OS) in patients with acute myeloid leukemia (AML) and to examine the potential role of allogeneic stem-cell transplantation (SCT) in this setting. Patients and Methods Data from 254 adult patients with AML (excluding acute promyelocytic leukemia) who achieved CR after induction chemotherapy on various first-line protocols were examined. Results Median follow-up for surviving patients was 43 months. Patients with cytogenetic abnormalities at CR (n = 71) had significantly shorter RFS (P = .001) and OS (P < .001) compared with patients with normal cytogenetics at CR (n = 183); 3-year RFS was 15% and 45%, and 3-year OS was 15% and 56%, respectively. Among the patients with persistent cytogenetic abnormalities at CR, those who underwent SCT in first CR (CR1; n = 15) had better RFS and OS compared to those without SCT (n = 56; P = .04 and .06, respectively). In multivariate analysis, persistent cytogenetic abnormalities at CR was an independent predictor for RFS (P < .001) and OS (P = .001), but among patients with persistent cytogenetic abnormalities at CR, no significant differences in OS (P = .25) was observed between those who did or did not receive SCT with a trend favoring SCT for RFS (P = .08). Conclusion Persistent cytogenetically abnormal cells at CR predict a significantly shorter RFS and OS. SCT in CR1 may improve the clinical outcome of patients lacking cytogenetic remission after induction although this depends on patient selection." @default.
• W2158154670 created "2016-06-24" @default.
• W2158154670 creator A5000750846 @default.
• W2158154670 creator A5001379257 @default.
• W2158154670 creator A5014719857 @default.
• W2158154670 creator A5015140142 @default.
• W2158154670 creator A5020340537 @default.
• W2158154670 creator A5030500582 @default.
• W2158154670 creator A5046097970 @default.
• W2158154670 creator A5057822243 @default.
• W2158154670 creator A5059138314 @default.
• W2158154670 creator A5061026876 @default.
• W2158154670 creator A5069460930 @default.
• W2158154670 creator A5084290698 @default.
• W2158154670 creator A5088821817 @default.
• W2158154670 creator A5090435894 @default.
• W2158154670 date "2011-06-20" @default.
• W2158154670 modified "2023-10-15" @default.
• W2158154670 title "Persistence of Cytogenetic Abnormalities at Complete Remission After Induction in Patients With Acute Myeloid Leukemia: Prognostic Significance and the Potential Role of Allogeneic Stem-Cell Transplantation" @default.
• W2158154670 cites W1534965621 @default.
• W2158154670 cites W1600095986 @default.
• W2158154670 cites W1685744202 @default.
• W2158154670 cites W1967471460 @default.
• W2158154670 cites W1974893528 @default.
• W2158154670 cites W1984938965 @default.
• W2158154670 cites W1992829933 @default.
• W2158154670 cites W1997487008 @default.
• W2158154670 cites W2005410572 @default.
• W2158154670 cites W2010571787 @default.
• W2158154670 cites W2018380183 @default.
• W2158154670 cites W2024763401 @default.
• W2158154670 cites W2029685076 @default.
• W2158154670 cites W2039642633 @default.
• W2158154670 cites W2043038685 @default.
• W2158154670 cites W2054098724 @default.
• W2158154670 cites W2071293034 @default.
• W2158154670 cites W2089596135 @default.
• W2158154670 cites W2096270095 @default.
• W2158154670 cites W2104127840 @default.
• W2158154670 cites W2113027268 @default.
• W2158154670 cites W2114165550 @default.
• W2158154670 cites W2118250079 @default.
• W2158154670 cites W2126212760 @default.
• W2158154670 cites W2128875589 @default.
• W2158154670 cites W2133262115 @default.
• W2158154670 cites W2148047805 @default.
• W2158154670 cites W2153382436 @default.
• W2158154670 cites W2159507916 @default.
• W2158154670 cites W2159738043 @default.
• W2158154670 cites W2159875685 @default.
• W2158154670 cites W2161996216 @default.
• W2158154670 cites W2162411731 @default.
• W2158154670 cites W2166634848 @default.
• W2158154670 cites W2409799523 @default.
• W2158154670 cites W2410089930 @default.
• W2158154670 cites W2414294675 @default.
• W2158154670 cites W4243761960 @default.
• W2158154670 cites W4376595466 @default.
• W2158154670 doi "https://doi.org/10.1200/jco.2010.34.2873" @default.
• W2158154670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4874214" @default.
• W2158154670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21555694" @default.
• W2158154670 hasPublicationYear "2011" @default.
• W2158154670 type Work @default.
• W2158154670 sameAs 2158154670 @default.
• W2158154670 citedByCount "59" @default.
• W2158154670 countsByYear W21581546702012 @default.
• W2158154670 countsByYear W21581546702013 @default.
• W2158154670 countsByYear W21581546702014 @default.
• W2158154670 countsByYear W21581546702015 @default.
• W2158154670 countsByYear W21581546702016 @default.
• W2158154670 countsByYear W21581546702017 @default.
• W2158154670 countsByYear W21581546702018 @default.
• W2158154670 countsByYear W21581546702019 @default.
• W2158154670 countsByYear W21581546702020 @default.
• W2158154670 countsByYear W21581546702021 @default.
• W2158154670 countsByYear W21581546702022 @default.
• W2158154670 countsByYear W21581546702023 @default.
• W2158154670 crossrefType "journal-article" @default.
• W2158154670 hasAuthorship W2158154670A5000750846 @default.
• W2158154670 hasAuthorship W2158154670A5001379257 @default.
• W2158154670 hasAuthorship W2158154670A5014719857 @default.
• W2158154670 hasAuthorship W2158154670A5015140142 @default.
• W2158154670 hasAuthorship W2158154670A5020340537 @default.
• W2158154670 hasAuthorship W2158154670A5030500582 @default.
• W2158154670 hasAuthorship W2158154670A5046097970 @default.
• W2158154670 hasAuthorship W2158154670A5057822243 @default.
• W2158154670 hasAuthorship W2158154670A5059138314 @default.
• W2158154670 hasAuthorship W2158154670A5061026876 @default.
• W2158154670 hasAuthorship W2158154670A5069460930 @default.
• W2158154670 hasAuthorship W2158154670A5084290698 @default.
• W2158154670 hasAuthorship W2158154670A5088821817 @default.
• W2158154670 hasAuthorship W2158154670A5090435894 @default.
• W2158154670 hasBestOaLocation W21581546701 @default.
• W2158154670 hasConcept C104317684 @default.
• W2158154670 hasConcept C126322002 @default.
• W2158154670 hasConcept C143998085 @default.
• W2158154670 hasConcept C174475383 @default.
• W2158154670 hasConcept C2776601000 @default.

• next