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- W2158161711 abstract "THE INTRODUCTION of potent orally administered diuretics has been one of the most significant therapeutic milestones of this century. It has had numerous unanticipated benefits, not the least of which is their key role in the management of hypertension. As with all potent agents, rational and safe use of these drugs is predicated on an understanding of their pharmacologic action and their potential side effects. <h3>DIURETIC AGENTS</h3><h3>Thiazide and Related Compounds</h3> All of the diuretics in Table 1 are sulfonamide derivatives although not all have the benzothiadiazine nucleus. Nevertheless, their pharmacologic properties and their effects on electrolyte excretion are so similar that they will be grouped together under the term thiazide for the purposes of this discussion. They inhibit sodium reabsorption in the cortical portion of the ascending tubule and in the distal convoluted tubule, where less than 10% of filtered sodium is reabsorbed. Consequently they are not as potent" @default.
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- W2158161711 date "1976-04-26" @default.
- W2158161711 modified "2023-10-18" @default.
- W2158161711 title "A Guide to the Practical Use of Diuretics" @default.
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- W2158161711 doi "https://doi.org/10.1001/jama.1976.03260430058034" @default.
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