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- W2158162318 abstract "Many mitochondrial proteins are synthesized with N-terminal presequences in the cytosol. The presequence translocase of the inner mitochondrial membrane (TIM23) translocates preproteins into and across the membrane and associates with the matrix-localized import motor. The TIM23 complex consists of three core components and Tim21, which interacts with the translocase of the outer membrane (TOM) and the respiratory chain. We have identified a new subunit of the TIM23 complex, the inner membrane protein Mgr2. Mitochondria lacking Mgr2 were deficient in the Tim21-containing sorting form of the TIM23 complex. Mgr2 was required for binding of Tim21 to TIM23CORE, revealing a binding chain of TIM23CORE-Mgr2/Tim21–respiratory chain. Mgr2-deficient yeast cells were defective in growth at elevated temperature, and the mitochondria were impaired in TOM-TIM23 coupling and the import of presequence-carrying preproteins. We conclude that Mgr2 is a coupling factor of the presequence translocase crucial for cell growth at elevated temperature and for efficient protein import." @default.
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- W2158162318 date "2012-05-21" @default.
- W2158162318 modified "2023-10-12" @default.
- W2158162318 title "Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes" @default.
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- W2158162318 doi "https://doi.org/10.1083/jcb.201110047" @default.
- W2158162318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3365495" @default.
- W2158162318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22613836" @default.
- W2158162318 hasPublicationYear "2012" @default.
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