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• W2158162812 abstract "ABSTRACT 1-Hydroxy-2-dodecyl-4(1 H )quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs and livers. Compound B showed a tendency toward lowering parasite loads in brains in a mouse model of toxoplasmic encephalitis." @default.
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• W2158162812 date "2010-01-01" @default.
• W2158162812 modified "2023-10-02" @default.
• W2158162812 title "In Vitro and In Vivo Activities of 1-Hydroxy-2-Alkyl-4(1 <i>H</i> )Quinolone Derivatives against <i>Toxoplasma gondii</i>" @default.
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• W2158162812 doi "https://doi.org/10.1128/aac.01001-09" @default.
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