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- W2158165001 abstract "It is now widely accepted that enzyme-catalysed C-H bond breakage occurs by quantum mechanical tunnelling. This paradigm shift in the conceptual framework for these reactions away from semi-classical transition state theory (TST, i.e. including zero-point energy, but with no tunnelling correction) has been driven over the recent years by experimental studies of the temperature dependence of kinetic isotope effects (KIEs) for these reactions in a range of enzymes, including the tryptophan tryptophylquinone-dependent enzymes such as methylamine dehydrogenase and aromatic amine dehydrogenase, and the flavoenzymes such as morphinone reductase and pentaerythritol tetranitrate reductase, which produced observations that are also inconsistent with the simple Bell-correction model of tunnelling. However, these data-especially, the strong temperature dependence of reaction rates and the variable temperature dependence of KIEs-are consistent with other tunnelling models (termed full tunnelling models), in which protein and/or substrate fluctuations generate a configuration compatible with tunnelling. These models accommodate substrate/protein (environment) fluctuations required to attain a configuration with degenerate nuclear quantum states and, when necessary, motion required to increase the probability of tunnelling in these states. Furthermore, tunnelling mechanisms in enzymes are supported by atomistic computational studies performed within the framework of modern TST, which incorporates quantum nuclear effects." @default.
- W2158165001 created "2016-06-24" @default.
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- W2158165001 date "2006-07-12" @default.
- W2158165001 modified "2023-10-10" @default.
- W2158165001 title "Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems" @default.
- W2158165001 cites W1487675418 @default.
- W2158165001 cites W1568612740 @default.
- W2158165001 cites W1681177208 @default.
- W2158165001 cites W1963630470 @default.
- W2158165001 cites W1965378620 @default.
- W2158165001 cites W1966444654 @default.
- W2158165001 cites W1969423952 @default.
- W2158165001 cites W1970547520 @default.
- W2158165001 cites W1970905224 @default.
- W2158165001 cites W1972173032 @default.
- W2158165001 cites W1976466905 @default.
- W2158165001 cites W1977794494 @default.
- W2158165001 cites W1979285357 @default.
- W2158165001 cites W1983225955 @default.
- W2158165001 cites W1984237617 @default.
- W2158165001 cites W1985588478 @default.
- W2158165001 cites W1985624549 @default.
- W2158165001 cites W1988449405 @default.
- W2158165001 cites W1991133713 @default.
- W2158165001 cites W1993916927 @default.
- W2158165001 cites W1996483373 @default.
- W2158165001 cites W1996690907 @default.
- W2158165001 cites W2003896818 @default.
- W2158165001 cites W2004303971 @default.
- W2158165001 cites W2004981069 @default.
- W2158165001 cites W2005015781 @default.
- W2158165001 cites W2008426408 @default.
- W2158165001 cites W2010634888 @default.
- W2158165001 cites W2011859576 @default.
- W2158165001 cites W2012983255 @default.
- W2158165001 cites W2013032090 @default.
- W2158165001 cites W2013410957 @default.
- W2158165001 cites W2014562537 @default.
- W2158165001 cites W2016148922 @default.
- W2158165001 cites W2018425793 @default.
- W2158165001 cites W2019900780 @default.
- W2158165001 cites W2022092718 @default.
- W2158165001 cites W2024757590 @default.
- W2158165001 cites W2025780460 @default.
- W2158165001 cites W2027612981 @default.
- W2158165001 cites W2027815611 @default.
- W2158165001 cites W2028474802 @default.
- W2158165001 cites W2031904472 @default.
- W2158165001 cites W2037353343 @default.
- W2158165001 cites W2040625467 @default.
- W2158165001 cites W2043901868 @default.
- W2158165001 cites W2048984271 @default.
- W2158165001 cites W2049507583 @default.
- W2158165001 cites W2051631220 @default.
- W2158165001 cites W2051893732 @default.
- W2158165001 cites W2052327916 @default.
- W2158165001 cites W2055389385 @default.
- W2158165001 cites W2064187591 @default.
- W2158165001 cites W2064590647 @default.
- W2158165001 cites W2066759906 @default.
- W2158165001 cites W2068502964 @default.
- W2158165001 cites W2073002099 @default.
- W2158165001 cites W2080658778 @default.
- W2158165001 cites W2081537969 @default.
- W2158165001 cites W2083210953 @default.
- W2158165001 cites W2084119857 @default.
- W2158165001 cites W2086035963 @default.
- W2158165001 cites W2086407132 @default.
- W2158165001 cites W2086434555 @default.
- W2158165001 cites W2087123471 @default.
- W2158165001 cites W2093061534 @default.
- W2158165001 cites W2096921126 @default.
- W2158165001 cites W2099322728 @default.
- W2158165001 cites W2100861430 @default.
- W2158165001 cites W2101217381 @default.
- W2158165001 cites W2107025108 @default.
- W2158165001 cites W2121260810 @default.
- W2158165001 cites W2121890116 @default.
- W2158165001 cites W2130479394 @default.
- W2158165001 cites W2139036153 @default.
- W2158165001 cites W2143183478 @default.
- W2158165001 cites W2145035598 @default.
- W2158165001 cites W2150454959 @default.
- W2158165001 cites W2151317179 @default.
- W2158165001 cites W2151896693 @default.
- W2158165001 cites W2154181301 @default.
- W2158165001 cites W2157199696 @default.
- W2158165001 cites W2160294964 @default.