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• W2158172497 abstract "Minocycline, a tetracycline with anti-inflammatory properties, has been reported to down-regulate the activity of microglia, whose activation occurs in inflammatory and degenerative diseases of the central nervous system, such as multiple sclerosis and Alzheimer's disease. In these disorders, a T cell component is also evident, and we have demonstrated previously that the interaction of activated T cells with microglia led to the substantial increase in tumor necrosis factor alpha (TNF-alpha) levels. Here, we report that minocycline decreases TNF-alpha levels produced in human T cell-microglia interaction. This effect is mediated by a direct action of minocycline on the activated T cells and on microglia, which resulted in the decreased ability of T cells to contact microglia. In correspondence, minocycline decreased the expression on T cells of the CD40 ligand (CD40L), a key molecule regulating the contact-mediated interaction of T cells with microglia. These results demonstrate that the mechanism of action of minocycline involves not only microglia but also T cells and their subsequent activation of microglia. The capacity of minocycline to down-regulate CD40L on T cells may provide a new means to target the CD40-CD40L pathway, which regulates several inflammatory processes." @default.
• W2158172497 created "2016-06-24" @default.
• W2158172497 creator A5060418334 @default.
• W2158172497 creator A5079991612 @default.
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• W2158172497 date "2005-04-13" @default.
• W2158172497 modified "2023-10-17" @default.
• W2158172497 title "Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction" @default.
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• W2158172497 doi "https://doi.org/10.1189/jlb.0804477" @default.
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