FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158177598> ?p ?o ?g. }

• W2158177598 endingPage "821" @default.
• W2158177598 startingPage "811" @default.
• W2158177598 abstract "Eps15 has been identified as a substrate of the EGF receptor tyrosine kinase. In this report, we show that activation of the EGF receptor by either EGF or TGF-α results in phosphorylation of Eps15. Stimulation of cells with PDGF or insulin did not lead to Eps15 phosphorylation, suggesting that phosphorylation of Eps15 is a receptor-specific process. We demonstrate that Eps15 is constitutively associated with both α-adaptin and clathrin. Upon EGF stimulation, Eps15 and α-adaptin are recruited to the EGF receptor. Using a truncated EGF receptor mutant, we demonstrate that the regulatory domain of the cytoplasmic tail of the EGF receptor is essential for the binding of Eps15. Fractionation studies reveal that Eps15 is present in cell fractions enriched for plasma membrane and endosomal membranes. Immunofluorescence studies show that Eps15 colocalizes with adaptor protein-2 (AP-2) and partially with clathrin. No colocalization of Eps15 was observed with the early endosomal markers rab4 and rab5. These observations indicate that Eps15 is present in coated pits and coated vesicles of the clathrin-mediated endocytic pathway, but not in early endosomes. Neither AP-2 nor clathrin are required for the binding of Eps15 to coated pits or coated vesicles, since in membranes lacking AP-2 and clathrin, Eps15 still shows the same staining pattern. These findings suggest that Eps15 may play a critical role in the recruitment of active EGF receptors into coated pit regions before endocytosis of ligand-occupied EGF receptors." @default.
• W2158177598 created "2016-06-24" @default.
• W2158177598 creator A5002361811 @default.
• W2158177598 creator A5008046685 @default.
• W2158177598 creator A5013056108 @default.
• W2158177598 creator A5017291474 @default.
• W2158177598 creator A5083767262 @default.
• W2158177598 date "1997-02-24" @default.
• W2158177598 modified "2023-10-13" @default.
• W2158177598 title "Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin" @default.
• W2158177598 cites W1487627529 @default.
• W2158177598 cites W1495480382 @default.
• W2158177598 cites W1496060898 @default.
• W2158177598 cites W1509317138 @default.
• W2158177598 cites W1535731511 @default.
• W2158177598 cites W1563405664 @default.
• W2158177598 cites W1720535299 @default.
• W2158177598 cites W1930849747 @default.
• W2158177598 cites W1963813812 @default.
• W2158177598 cites W1972960760 @default.
• W2158177598 cites W1985670865 @default.
• W2158177598 cites W1992139451 @default.
• W2158177598 cites W1996376778 @default.
• W2158177598 cites W1997662437 @default.
• W2158177598 cites W1999281989 @default.
• W2158177598 cites W2008611743 @default.
• W2158177598 cites W2030210725 @default.
• W2158177598 cites W2031546084 @default.
• W2158177598 cites W2032359283 @default.
• W2158177598 cites W2035584408 @default.
• W2158177598 cites W2042013644 @default.
• W2158177598 cites W2050222635 @default.
• W2158177598 cites W2053469492 @default.
• W2158177598 cites W2056701485 @default.
• W2158177598 cites W2061671663 @default.
• W2158177598 cites W2065365365 @default.
• W2158177598 cites W2065378127 @default.
• W2158177598 cites W2080409394 @default.
• W2158177598 cites W2085889179 @default.
• W2158177598 cites W2095939432 @default.
• W2158177598 cites W2120190946 @default.
• W2158177598 cites W2142925367 @default.
• W2158177598 cites W2150551823 @default.
• W2158177598 cites W2164682544 @default.
• W2158177598 cites W2164797945 @default.
• W2158177598 cites W2474157163 @default.
• W2158177598 doi "https://doi.org/10.1083/jcb.136.4.811" @default.
• W2158177598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2132490" @default.
• W2158177598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9049247" @default.
• W2158177598 hasPublicationYear "1997" @default.
• W2158177598 type Work @default.
• W2158177598 sameAs 2158177598 @default.
• W2158177598 citedByCount "122" @default.
• W2158177598 countsByYear W21581775982012 @default.
• W2158177598 countsByYear W21581775982014 @default.
• W2158177598 countsByYear W21581775982015 @default.
• W2158177598 countsByYear W21581775982016 @default.
• W2158177598 countsByYear W21581775982017 @default.
• W2158177598 countsByYear W21581775982019 @default.
• W2158177598 countsByYear W21581775982021 @default.
• W2158177598 crossrefType "journal-article" @default.
• W2158177598 hasAuthorship W2158177598A5002361811 @default.
• W2158177598 hasAuthorship W2158177598A5008046685 @default.
• W2158177598 hasAuthorship W2158177598A5013056108 @default.
• W2158177598 hasAuthorship W2158177598A5017291474 @default.
• W2158177598 hasAuthorship W2158177598A5083767262 @default.
• W2158177598 hasBestOaLocation W21581775981 @default.
• W2158177598 hasConcept C102747710 @default.
• W2158177598 hasConcept C11960822 @default.
• W2158177598 hasConcept C130316041 @default.
• W2158177598 hasConcept C139770010 @default.
• W2158177598 hasConcept C170493617 @default.
• W2158177598 hasConcept C183786373 @default.
• W2158177598 hasConcept C28005876 @default.
• W2158177598 hasConcept C40209533 @default.
• W2158177598 hasConcept C41625074 @default.
• W2158177598 hasConcept C55493867 @default.
• W2158177598 hasConcept C63162447 @default.
• W2158177598 hasConcept C79879829 @default.
• W2158177598 hasConcept C86803240 @default.
• W2158177598 hasConcept C95444343 @default.
• W2158177598 hasConceptScore W2158177598C102747710 @default.
• W2158177598 hasConceptScore W2158177598C11960822 @default.
• W2158177598 hasConceptScore W2158177598C130316041 @default.
• W2158177598 hasConceptScore W2158177598C139770010 @default.
• W2158177598 hasConceptScore W2158177598C170493617 @default.
• W2158177598 hasConceptScore W2158177598C183786373 @default.
• W2158177598 hasConceptScore W2158177598C28005876 @default.
• W2158177598 hasConceptScore W2158177598C40209533 @default.
• W2158177598 hasConceptScore W2158177598C41625074 @default.
• W2158177598 hasConceptScore W2158177598C55493867 @default.
• W2158177598 hasConceptScore W2158177598C63162447 @default.
• W2158177598 hasConceptScore W2158177598C79879829 @default.
• W2158177598 hasConceptScore W2158177598C86803240 @default.
• W2158177598 hasConceptScore W2158177598C95444343 @default.
• W2158177598 hasIssue "4" @default.
• W2158177598 hasLocation W21581775981 @default.
• W2158177598 hasLocation W21581775982 @default.

• next