Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158207944> ?p ?o ?g. }
- W2158207944 endingPage "219" @default.
- W2158207944 startingPage "191" @default.
- W2158207944 abstract "▪ Abstract Various physicochemical factors influence DNA replication fidelity. Since it is now known that Watson-Crick hydrogen bonds are not necessary for efficient and selective replication of a base pair by DNA polymerase enzymes, a number of alternative physical factors have been examined to explain the efficiency of these enzymes. Among these factors are minor groove hydrogen bonding, base stacking, solvation, and steric effects. We discuss the concept of active site tightness in DNA polymerases, and consider how it might influence steric (size and shape) effects of nucleotide selection in synthesis of a base pair. A high level of active site tightness is expected to lead to higher fidelity relative to proteins with looser active sites. We review the current data on what parts and dimensions of active sites are most affected by size and shape, based on data with modified nucleotides that have been examined as polymerase substrates. We also discuss recent data on nucleotide analogs displaying higher fidelity than the natural ones. The published data are discussed with a view toward testing this sterically based hypothesis and unifying existing observations into a narrowly defined range of effects." @default.
- W2158207944 created "2016-06-24" @default.
- W2158207944 creator A5078529502 @default.
- W2158207944 date "2002-06-01" @default.
- W2158207944 modified "2023-10-10" @default.
- W2158207944 title "Active Site Tightness and Substrate Fit in DNA Replication" @default.
- W2158207944 cites W1493170168 @default.
- W2158207944 cites W1509356220 @default.
- W2158207944 cites W1510371408 @default.
- W2158207944 cites W1511852170 @default.
- W2158207944 cites W1547544053 @default.
- W2158207944 cites W1557374814 @default.
- W2158207944 cites W1574673445 @default.
- W2158207944 cites W1576472122 @default.
- W2158207944 cites W1581466567 @default.
- W2158207944 cites W1605298634 @default.
- W2158207944 cites W1608869439 @default.
- W2158207944 cites W1939421214 @default.
- W2158207944 cites W1964626270 @default.
- W2158207944 cites W1964673927 @default.
- W2158207944 cites W1964869773 @default.
- W2158207944 cites W1967941593 @default.
- W2158207944 cites W1968034613 @default.
- W2158207944 cites W1968937894 @default.
- W2158207944 cites W1972105243 @default.
- W2158207944 cites W1972391424 @default.
- W2158207944 cites W1973711348 @default.
- W2158207944 cites W1977112287 @default.
- W2158207944 cites W1978910509 @default.
- W2158207944 cites W1981732831 @default.
- W2158207944 cites W1984206638 @default.
- W2158207944 cites W1988294547 @default.
- W2158207944 cites W1988669301 @default.
- W2158207944 cites W1989955252 @default.
- W2158207944 cites W1991086259 @default.
- W2158207944 cites W1992600590 @default.
- W2158207944 cites W1993452701 @default.
- W2158207944 cites W1994418194 @default.
- W2158207944 cites W1994497887 @default.
- W2158207944 cites W1996080607 @default.
- W2158207944 cites W1996371195 @default.
- W2158207944 cites W1997383963 @default.
- W2158207944 cites W1999846964 @default.
- W2158207944 cites W2000337414 @default.
- W2158207944 cites W2004499709 @default.
- W2158207944 cites W2011883398 @default.
- W2158207944 cites W2013544902 @default.
- W2158207944 cites W2013980088 @default.
- W2158207944 cites W2015472931 @default.
- W2158207944 cites W2020647944 @default.
- W2158207944 cites W2025962542 @default.
- W2158207944 cites W2027179930 @default.
- W2158207944 cites W2030765285 @default.
- W2158207944 cites W2031596792 @default.
- W2158207944 cites W2032200612 @default.
- W2158207944 cites W2038185700 @default.
- W2158207944 cites W2040984741 @default.
- W2158207944 cites W2041790700 @default.
- W2158207944 cites W2043628429 @default.
- W2158207944 cites W2044933165 @default.
- W2158207944 cites W2046127685 @default.
- W2158207944 cites W2046290782 @default.
- W2158207944 cites W2046387060 @default.
- W2158207944 cites W2052484845 @default.
- W2158207944 cites W2054423031 @default.
- W2158207944 cites W2057213837 @default.
- W2158207944 cites W2057446591 @default.
- W2158207944 cites W2057977031 @default.
- W2158207944 cites W2060720286 @default.
- W2158207944 cites W2062148408 @default.
- W2158207944 cites W2063308005 @default.
- W2158207944 cites W2063502275 @default.
- W2158207944 cites W2064879624 @default.
- W2158207944 cites W2066449629 @default.
- W2158207944 cites W2066574980 @default.
- W2158207944 cites W2067816441 @default.
- W2158207944 cites W2072148275 @default.
- W2158207944 cites W2075609974 @default.
- W2158207944 cites W2078641463 @default.
- W2158207944 cites W2081653306 @default.
- W2158207944 cites W2084616101 @default.
- W2158207944 cites W2085217231 @default.
- W2158207944 cites W2085295246 @default.
- W2158207944 cites W2087636093 @default.
- W2158207944 cites W2087814255 @default.
- W2158207944 cites W2088979606 @default.
- W2158207944 cites W2089898350 @default.
- W2158207944 cites W2094550156 @default.
- W2158207944 cites W2097432692 @default.
- W2158207944 cites W2103585578 @default.
- W2158207944 cites W2106386452 @default.
- W2158207944 cites W2107520545 @default.
- W2158207944 cites W2115495932 @default.
- W2158207944 cites W2120072997 @default.
- W2158207944 cites W2127313259 @default.
- W2158207944 cites W2127753323 @default.
- W2158207944 cites W2129073323 @default.
- W2158207944 cites W2135343804 @default.