Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158212099> ?p ?o ?g. }
- W2158212099 endingPage "2050" @default.
- W2158212099 startingPage "2045" @default.
- W2158212099 abstract "ABSTRACT Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) transactivates EBV genes in latently infected B cells. We have shown that mitotic hyperphosphorylation of EBNA2 suppresses its ability to transactivate the latent membrane protein 1 (LMP1) promoter. In this follow-up study, we identify EBNA2 Ser243 as a phosphorylation site for mitotic cdc2/cyclin B1 kinase. Mutation at Ser243, which mimics constitutive phosphorylation of the protein, decreases endogenous levels of both LMP1 and EBNA2. Moreover, mutation at Ser243 reduces the ability of EBNA2 to transactivate Cp, the promoter for all six EBV EBNA genes. Our data implicate EBNA2 Ser243 as a cdc2/cyclin B1 site of phosphorylation important for EBNA2's cotranscriptional function in mitosis." @default.
- W2158212099 created "2016-06-24" @default.
- W2158212099 creator A5062701543 @default.
- W2158212099 creator A5075719027 @default.
- W2158212099 creator A5081306475 @default.
- W2158212099 date "2006-02-15" @default.
- W2158212099 modified "2023-09-26" @default.
- W2158212099 title "cdc2/Cyclin B1-Dependent Phosphorylation of EBNA2 at Ser243 Regulates Its Function in Mitosis" @default.
- W2158212099 cites W1504511808 @default.
- W2158212099 cites W1520599149 @default.
- W2158212099 cites W1559069009 @default.
- W2158212099 cites W1576118697 @default.
- W2158212099 cites W1600425139 @default.
- W2158212099 cites W1607340293 @default.
- W2158212099 cites W1812374189 @default.
- W2158212099 cites W1899316739 @default.
- W2158212099 cites W1975216103 @default.
- W2158212099 cites W1980442677 @default.
- W2158212099 cites W1985082049 @default.
- W2158212099 cites W1993839005 @default.
- W2158212099 cites W2011233324 @default.
- W2158212099 cites W2017050402 @default.
- W2158212099 cites W2019526281 @default.
- W2158212099 cites W2021464282 @default.
- W2158212099 cites W2034317592 @default.
- W2158212099 cites W2055790677 @default.
- W2158212099 cites W2057081519 @default.
- W2158212099 cites W2058144279 @default.
- W2158212099 cites W2059974962 @default.
- W2158212099 cites W2071151226 @default.
- W2158212099 cites W2071171955 @default.
- W2158212099 cites W2073503477 @default.
- W2158212099 cites W2085037886 @default.
- W2158212099 cites W2085220509 @default.
- W2158212099 cites W2091702992 @default.
- W2158212099 cites W2096784993 @default.
- W2158212099 cites W2110980603 @default.
- W2158212099 cites W2111386157 @default.
- W2158212099 cites W2120514938 @default.
- W2158212099 cites W2123930515 @default.
- W2158212099 cites W2136105013 @default.
- W2158212099 cites W2141616119 @default.
- W2158212099 cites W2145623629 @default.
- W2158212099 cites W2145744353 @default.
- W2158212099 cites W2151190049 @default.
- W2158212099 cites W2151473316 @default.
- W2158212099 cites W2157106451 @default.
- W2158212099 cites W2158982274 @default.
- W2158212099 cites W2159117635 @default.
- W2158212099 cites W2163446263 @default.
- W2158212099 cites W2167839640 @default.
- W2158212099 cites W2292489492 @default.
- W2158212099 cites W2424085648 @default.
- W2158212099 doi "https://doi.org/10.1128/jvi.80.4.2045-2050.2006" @default.
- W2158212099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1367142" @default.
- W2158212099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16439560" @default.
- W2158212099 hasPublicationYear "2006" @default.
- W2158212099 type Work @default.
- W2158212099 sameAs 2158212099 @default.
- W2158212099 citedByCount "12" @default.
- W2158212099 countsByYear W21582120992014 @default.
- W2158212099 countsByYear W21582120992017 @default.
- W2158212099 countsByYear W21582120992021 @default.
- W2158212099 countsByYear W21582120992022 @default.
- W2158212099 crossrefType "journal-article" @default.
- W2158212099 hasAuthorship W2158212099A5062701543 @default.
- W2158212099 hasAuthorship W2158212099A5075719027 @default.
- W2158212099 hasAuthorship W2158212099A5081306475 @default.
- W2158212099 hasBestOaLocation W21582120992 @default.
- W2158212099 hasConcept C104317684 @default.
- W2158212099 hasConcept C11960822 @default.
- W2158212099 hasConcept C120089663 @default.
- W2158212099 hasConcept C120504264 @default.
- W2158212099 hasConcept C153911025 @default.
- W2158212099 hasConcept C16438837 @default.
- W2158212099 hasConcept C2778198054 @default.
- W2158212099 hasConcept C2778437423 @default.
- W2158212099 hasConcept C29537977 @default.
- W2158212099 hasConcept C502942594 @default.
- W2158212099 hasConcept C54355233 @default.
- W2158212099 hasConcept C86803240 @default.
- W2158212099 hasConcept C93304396 @default.
- W2158212099 hasConcept C95444343 @default.
- W2158212099 hasConcept C9743823 @default.
- W2158212099 hasConceptScore W2158212099C104317684 @default.
- W2158212099 hasConceptScore W2158212099C11960822 @default.
- W2158212099 hasConceptScore W2158212099C120089663 @default.
- W2158212099 hasConceptScore W2158212099C120504264 @default.
- W2158212099 hasConceptScore W2158212099C153911025 @default.
- W2158212099 hasConceptScore W2158212099C16438837 @default.
- W2158212099 hasConceptScore W2158212099C2778198054 @default.
- W2158212099 hasConceptScore W2158212099C2778437423 @default.
- W2158212099 hasConceptScore W2158212099C29537977 @default.
- W2158212099 hasConceptScore W2158212099C502942594 @default.
- W2158212099 hasConceptScore W2158212099C54355233 @default.
- W2158212099 hasConceptScore W2158212099C86803240 @default.
- W2158212099 hasConceptScore W2158212099C93304396 @default.
- W2158212099 hasConceptScore W2158212099C95444343 @default.