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• W2158214594 abstract "As encefalopatias espongiformes transmissiveis (EETs), ou doencas prionicas, sao um grupo de doencas infecciosas neurodegenerativas que conduzem seus portadores a morte. Ainda sem cura e formas de prevencao, as EETs ganham cada vez mais importância a medida que novos estudos tem mostrado sua abrangente disseminacao mundial e a grande quantidade de grupos animais susceptiveis ao desenvolvimento das doencas. As EETs mais popularmente conhecidas sao a doenca de Creutzfeldt-Jacob em humanos, a Encefalopatia Espongiforme Bovina (BSE) e o scrapie em ovinos. Outra forma de encefalopatia menos conhecida, mas nao menos importante, e a Doenca da Debilidade Cronica (CWD) que acomete especies da familia Cervidae . A CWD diferencia-se das demais EETs por ser a unica forma conhecida da doenca que ataca animais selvagens. Estudos nos EUA, Canada e Coreia do Sul tem mostrado um padrao bastante preciso do desenvolvimento da CWD associado a polimorfismos especificos no gene Prnp . Apesar de ser considerada uma epidemia nos Estados Unidos, e diversos programas de vigilância de vida selvagem estarem em curso com intuito de detectar e minimizar a propagacao da CWD ao redor do mundo, no Brasil ainda nao foram registrados casos da doenca e ate o momento apenas um grupo de pesquisa vem se dedicando a estuda-la. SUMMARY Transmissible spongiform encephalopathy (TSE), or prion diseases, are a group of infectious neurodegenerative diseases, which leads the hosts to death. Without available healing and prevention programs, TSE becomes more important as new researches have shown its comprehensive global spread and the large number of animal groups susceptible to developing TSEs. The most popular TSEs are Creutzfeldt-Jacob disease in humans, Bovine Spongiform Encephalopathy (BSE), and scrapie in ovine. Another prion disease less known, but not less important, is the Chronic Wasting Disease (CWD) which attacks animals from Cervidae family, and is the only form of TSE that attacks wild animals. Recent studies from the Unites States, Canada and South Korea have shown a well-established pattern of CWD development associated with specific nucleotide polymorphisms in the Prnp gene. Despite being considered an epidemic in the United States and with many programs of wildlife vigilance being developed to detect and reduce the spread of CWD around the world, in Brazil, there are no registered cases of CWD yet, and only one research group is working with this disease at this time." @default.
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• W2158214594 date "2012-03-28" @default.
• W2158214594 modified "2023-09-26" @default.
• W2158214594 title "CHRONIC WASTING DISEASE: THE PRION DISEASE OF CERVIDS / Doença da debilidade crônica: a doença priônica dos cervídeos." @default.
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