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• W2158221444 endingPage "576" @default.
• W2158221444 startingPage "570" @default.
• W2158221444 abstract "Macrophage cholesterol accumulation and foam cell formation are the hallmarks of early atherogenesis. Pomegranate juice (PJ) was shown to inhibit macrophage foam cell formation and development of atherosclerotic lesions. The aim of this study was to elucidate possible mechanisms by which PJ reduces cholesterol accumulation in macrophages. J774.A1 macrophages were preincubated with PJ followed by analysis of cholesterol influx [evaluated as LDL or as oxidized LDL (Ox-LDL) cellular degradation], cholesterol efflux and cholesterol biosynthesis. Preincubation of macrophages with PJ resulted in a significant reduction (P<.01) in Ox-LDL degradation by 40%. On the contrary, PJ had no effect on macrophage degradation of native LDL or on macrophage cholesterol efflux. Macrophage cholesterol biosynthesis was inhibited by 50% (P<.01) after cell incubation with PJ. This inhibition, however, was not mediated at the 3-hydroxy-3 methylglutaryl coenzyme A reductase level along the biosynthetic pathway. We conclude that PJ-mediated suppression of Ox-LDL degradation and of cholesterol biosynthesis in macrophages can lead to reduced cellular cholesterol accumulation and foam cell formation." @default.
• W2158221444 created "2016-06-24" @default.
• W2158221444 creator A5004547600 @default.
• W2158221444 creator A5016973217 @default.
• W2158221444 creator A5052487247 @default.
• W2158221444 date "2005-09-01" @default.
• W2158221444 modified "2023-09-28" @default.
• W2158221444 title "Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages" @default.
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• W2158221444 doi "https://doi.org/10.1016/j.jnutbio.2005.02.009" @default.
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• W2158221444 hasPublicationYear "2005" @default.
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