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- W2158221898 abstract "Synthesis of deaminocolchinyl methyl ether 9 was achieved from tetramethoxy-substituted biphenyl-2-carb-aldehyde 12 via tricyclic ketone 20 and 5,6-didehydro congener 11. Compound 9 was identical in every respect with material prepared from colchicine via 6,7-didehydro congener 10. Measuring inhibition of tubulin polymerization in vitro showed compounds 4, 5, and 9–11 of the alloseries of colchicinoids to be particularly potent inhibitors." @default.
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- W2158221898 date "1989-12-13" @default.
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- W2158221898 title "Deaminocolchinyl Methyl Ether: Synthesis from 2,3,4,4′-Tetramethoxybiphenyl-2-carbaldehyde. Comparison of antitubulin effects of deaminocolchinyl methyl ether and dehydro analogs" @default.
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- W2158221898 doi "https://doi.org/10.1002/hlca.19890720805" @default.
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