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• W2158227890 startingPage "4252" @default.
• W2158227890 abstract "ABSTRACT Pneumocystis species are opportunistic fungal pathogens that induce tumor necrosis factor (TNF) production by alveolar macrophages. Here we report that B cells from the draining lymph nodes as well as lung CD4 + T cells are important producers of TNF upon Pneumocystis murina infection. To determine the importance of B cell-derived TNF in the primary response to P. murina , we generated bone marrow chimeras whose B cells were unable to produce TNF. The lung P. murina burden at 10 days postinfection in TNF knockout (TNFKO) chimeras was significantly higher than that in wild-type (WT) chimeras, which corresponded to reduced numbers of activated CD4 + T cells in the lungs at this early time point. Furthermore, CD4 + T cells isolated from P. murina -infected TNFKO chimeras were unable to stimulate clearance of P. murina upon adoptive transfer to recombinase-deficient (RAG1KO) hosts. Together, these data indicate that B cell-derived TNF plays an important function in promoting CD4 + T cell expansion and production of TNF and facilitating protection against P. murina infection." @default.
• W2158227890 created "2016-06-24" @default.
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• W2158227890 date "2013-11-01" @default.
• W2158227890 modified "2023-09-25" @default.
• W2158227890 title "B Cell Production of Tumor Necrosis Factor in Response to Pneumocystis murina Infection in Mice" @default.
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• W2158227890 doi "https://doi.org/10.1128/iai.00744-13" @default.
• W2158227890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3811839" @default.
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• W2158227890 hasPublicationYear "2013" @default.
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