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- W2158235526 abstract "Abstract The severity of Staphylococcus aureus sepsis is positively associated with staphylococcal enterotoxin A (SEA) and negatively associated with the enterotoxin gene cluster (egc), which encodes five staphylococcal enterotoxins [1]. We postulated that the variable, clinical severity of S. aureus sepsis might be a result of differences in the inflammatory properties of staphylococcal superantigens. We therefore compared the inflammatory properties of SEA with those of staphylococcal entérotoxin G (SEG), a member of the five egc superantigens. We found that SEA and SEG had similar superantigenic properties, as they induced CD69 expression on T lymphocytes and selective expansion of Vβ subpopulations. Contrary to SEG, however, SEA induced a strong proinflammatory/Th1 response, including TNF-α and MIP-1α production. These results suggest that the association of SEA with the severity of S. aureus septic shock, characterized by a deleterious, inflammatory cascade, may be explained partly by the specific proinflammatory properties of this superantigen." @default.
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- W2158235526 date "2006-08-02" @default.
- W2158235526 modified "2023-10-16" @default.
- W2158235526 title "Comparative inflammatory properties of staphylococcal superantigenic enterotoxins SEA and SEG: implications for septic shock" @default.
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- W2158235526 doi "https://doi.org/10.1189/jlb.0306232" @default.
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