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• W2158253794 abstract "Within the central nervous system (CNS), antigen-presenting cells (APCs) play a critical role in orchestrating inflammatory responses where they present CNS-derived antigens to immune cells that are recruited from the circulation to the cerebrospinal fluid, parenchyma, and perivascular space. Available data indicate that APCs do so indirectly from outside of CNS vessels without direct access to luminal contents. Here, we applied high-resolution, dynamic intravital two-photon laser scanning microscopy to directly visualize extravascular CX3CR1+ APC behavior deep within undisrupted CNS tissues in two distinct anatomical sites under three different inflammatory stimuli. Surprisingly, we observed that CNS-resident APCs dynamically extend their cellular processes across an intact vessel wall into the vascular lumen with preservation of vessel integrity. While only a small number of APCs displayed intravascular extensions in intact, noninflamed vessels in the brain and the spinal cord, the frequency of projections increased over days in an experimental autoimmune encephalomyelitis model, whereas the number of projections remained stable compared to baseline days after tissue injury such as CNS tumor infiltration and aseptic spinal cord trauma. Our observation of this unique behavior by parenchyma CX3CR1+ cells in the CNS argues for further exploration into their functional role in antigen sampling and immune cell recruitment." @default.
• W2158253794 created "2016-06-24" @default.
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• W2158253794 date "2013-05-03" @default.
• W2158253794 modified "2023-10-11" @default.
• W2158253794 title "Extravascular CX3CR1⁺Cells Extend Intravascular Dendritic Processes into Intact Central Nervous System Vessel Lumen" @default.
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• W2158253794 doi "https://doi.org/10.1017/s1431927613000482" @default.
• W2158253794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3933819" @default.
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• W2158253794 hasPublicationYear "2013" @default.
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