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- W2158256410 abstract "State Key Lab for Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing China 100101.The neurons integrate signals from numerous synaptic inputs and produce sequential action potentials as digital codes to carry various messages of controlling well-organized behaviors and cognition. In terms of the source for their initiation, short-time depolarization pulses evoke a single spike at axon hillock. However, action potentials at the neurons in vivo are induced by long-time depolarization. The source for long-duration signals to induce digital spikes needs to be addressed, which we studied at pyramidal neurons in layer 4 of cortical slices by dual-recording on the soma and axonal bleb of identical neurons. In intracellular recording in vivo, the duration of membrane depolarization falls into a range of 60∼1600 ms. These depolarization pulses were injected into the soma and axon of identical cortical pyramidal neurons to induce spikes. Theoretically, the primary location for spikes’ encoding should have more efficient input-output and the highest ability to fire sequential spikes. In whole-cell recording, these physiological signals induce somatic spikes with efficient input-output, the highest spiking ability, lower thresholds and shorter refractory periods, compared with axonal ones. In single-channel recording, voltage-gated sodium channels (VGSC) during a pre-depolarization, which mimics long-time signals, show less inactivation and easier reactivation at the soma than axon. Less inactivated and easily reactivated somatic VGSCs in Neuron model simulate a somatic source of sequential spikes. Based on our data from experiments to theoretical modeling and computational simulation back to experiments, we conclude that physiological inputs primarily trigger the soma to encode neuronal digital signals." @default.
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- W2158256410 date "2011-02-01" @default.
- W2158256410 modified "2023-09-26" @default.
- W2158256410 title "Soma as a Source of Sequential Spikes at Cortical Pyramidal Neurons" @default.
- W2158256410 doi "https://doi.org/10.1016/j.bpj.2010.12.2503" @default.
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