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• W2158261195 startingPage "557" @default.
• W2158261195 abstract "BALB/MK mouse epidermal keratinocytes require epidermal growth factor (EGF) for proliferation and terminally differentiate in response to high calcium concentrations. We show that EGF is an extremely potent mitogen, causing BALB/MK cultures to enter the cell cycle in a synchronous manner associated with a greater than 100-fold increase in DNA synthesis. Analysis of the expression of proto-oncogenes which have been reported to be activated during the cascade of events following growth factor stimulation of fibroblasts or lymphoid cells revealed a very rapid but transient 100-fold increase in c-fos RNA but little or no effect on the other proto-oncogenes analyzed. Exposure of EGF-synchronized BALB/MK cells to high levels of calcium was associated with a striking decrease in the early burst of c-fos RNA as well as the subsequent peak of cell DNA synthesis. Since the inhibitory effect of high calcium on c-fos RNA expression was measurable within 30 min, our studies imply that the EGF proliferative and calcium differentiation signals must interact very early in the pathway of EGF-induced proliferation. Our results also establish that c-fos RNA modulation is an important early marker of cell proliferation in epithelial as well as mesenchymal cells." @default.
• W2158261195 created "2016-06-24" @default.
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• W2158261195 date "1988-02-01" @default.
• W2158261195 modified "2023-09-26" @default.
• W2158261195 title "The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway." @default.
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• W2158261195 doi "https://doi.org/10.1128/mcb.8.2.557" @default.
• W2158261195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/363180" @default.
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• W2158261195 hasPublicationYear "1988" @default.
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